The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases

by James A. Shayman, Scott D. Larsen
Published 2014-07-01

Novel inhibitors of Staphylococcus aureus virulence gene expression and biofilm formation.

by Yibao Ma, Yuanxi Xu, Bryan D Yestrepsky, Roderick J Sorenson, Meng Chen, Scott D Larsen, Hongmin Sun
Published 2012-01-01

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway

by Jessica L. Bell, Andrew J. Haak, Susan M. Wade, Yihan Sun, Richard R. Neubig, Scott D. Larsen
Published 2013-05-01

Physicochemical properties and formulation development of a novel compound inhibiting Staphylococcus aureus biofilm formation.

by Nan Wang, Feng Qi, Haqing Yu, Bryan D Yestrepsky, Scott D Larsen, Honglan Shi, Juan Ji, David W Anderson, Hao Li, Hongmin Sun
Published 2021-01-01

In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis

by Aristides D. Tagalakis, Shivam Madaan, Scott D. Larsen, Richard R. Neubig, Peng T. Khaw, Ian Rodrigues, Saurabh Goyal, Kin Sheng Lim, Cynthia Yu-Wai-Man
Published 2018-11-01

Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain

by Scott D. Larsen, Michael W. Wilson, Akira Abe, Liming Shu, Christopher H. George, Paul Kirchhoff, H. D. Hollis Showalter, Jianming Xiang, Richard F. Keep, James A. Shayman
Published 2012-02-01

Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis

by Cynthia Yu-Wai-Man, Bradley Spencer-Dene, Richard M. H. Lee, Kim Hutchings, Erika M. Lisabeth, Richard Treisman, Maryse Bailly, Scott D. Larsen, Richard R. Neubig, Peng T. Khaw
Published 2017-03-01

Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

by Michael W. Beck, Jeffrey S. Derrick, Richard A. Kerr, Shin Bi Oh, Woo Jong Cho, Shin Jung C. Lee, Yonghwan Ji, Jiyeon Han, Zahra Aliakbar Tehrani, Nayoung Suh, Sujeong Kim, Scott D. Larsen, Kwang S. Kim, Joo-Yong Lee, Brandon T. Ruotolo, Mi Hee Lim
Published 2016-10-01

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

by Ilana Chefetz, Edward Grimley, Kun Yang, Linda Hong, Ekaterina V. Vinogradova, Radu Suciu, Ilya Kovalenko, David Karnak, Cynthia A. Morgan, Mikhail Chtcherbinine, Cameron Buchman, Brandt Huddle, Scott Barraza, Meredith Morgan, Kara A. Bernstein, Euisik Yoon, David B. Lombard, Andrea Bild, Geeta Mehta, Iris Romero, Chun-Yi Chiang, Charles Landen, Benjamin Cravatt, Thomas D. Hurley, Scott D. Larsen, Ronald J. Buckanovich
Published 2019-03-01