Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans

by Marija Zaric, Arianna Marini, Carolyn M. Nielsen, Gaurav Gupta, David Mekhaiel, Thao P. Pham, Sean C. Elias, Iona J. Taylor, Hans de Graaf, Ruth O. Payne, Yuanyuan Li, Sarah E. Silk, Chris Williams, Adrian V. S. Hill, Carole A. Long, Kazutoyo Miura, Sumi Biswas
Published 2021-09-01

Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposure.

by Sumi Biswas, Prateek Choudhary, Sean C Elias, Kazutoyo Miura, Kathryn H Milne, Simone C de Cassan, Katharine A Collins, Fenella D Halstead, Carly M Bliss, Katie J Ewer, Faith H Osier, Susanne H Hodgson, Christopher J A Duncan, Geraldine A O'Hara, Carole A Long, Adrian V S Hill, Simon J Draper
Published 2014-01-01

Changes in Serological Immunology Measures in UK and Kenyan Adults Post-Controlled Human Malaria Infection

by Susanne Helena Hodgson, David Llewellyn, Sarah Silk, Kathryn H Milne, Sean C Elias, Kazutoyo Miura, Gathoni Kamuyu, Elizabeth Juma, Charles Magiri, Alfred Musau Muia, Jing Jin, Alexandra J Spencer, Rhea Jessica Longley, Thomas Mercier, Laurent Decosterd, Carole A Long, Faith HA Osier, Stephen Hoffman, Bernhards Ragama Ogutu, Adrian V.S. Hill, Kevin Marsh, Simon J Draper
Published 2016-10-01

Preclinical assessment of viral vectored and protein vaccines targeting the Duffy-binding protein region II of Plasmodium vivax

by Simone C de Cassan, A. Rushdi Shakri, David eLlewellyn, Sean C Elias, Jee Sun Cho, Jee Sun Cho, Anna L Goodman, Jing eJin, Alexander D Douglas, Rossarin eSuwanarusk, Rossarin eSuwanarusk, François H Nosten, Laurent eRénia, Laurent eRénia, Bruce eRussell, Chetan E Chitnis, Chetan E Chitnis, Simon J Draper
Published 2015-07-01

Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial

by Hans de Graaf, Ruth O. Payne, Iona Taylor, Kazutoyo Miura, Carol A. Long, Sean C. Elias, Marija Zaric, Angela M. Minassian, Sarah E. Silk, Lee Li, Ian D. Poulton, Megan Baker, Simon J. Draper, Diane Gbesemete, Nathan J. Brendish, Filipa Martins, Arianna Marini, David Mekhaiel, Nick J. Edwards, Rachel Roberts, Johan Vekemans, Sarah Moyle, Saul N. Faust, Eleanor Berrie, Alison M. Lawrie, Fergal Hill, Adrian V. S. Hill, Sumi Biswas
Published 2021-07-01

Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors.

by Susanne H Sheehy, Christopher J A Duncan, Sean C Elias, Sumi Biswas, Katharine A Collins, Geraldine A O'Hara, Fenella D Halstead, Katie J Ewer, Tabitha Mahungu, Alexandra J Spencer, Kazutoyo Miura, Ian D Poulton, Matthew D J Dicks, Nick J Edwards, Eleanor Berrie, Sarah Moyle, Stefano Colloca, Riccardo Cortese, Katherine Gantlett, Carole A Long, Alison M Lawrie, Sarah C Gilbert, Tom Doherty, Alfredo Nicosia, Adrian V S Hill, Simon J Draper
Published 2012-01-01

Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans

by Pramila Rijal, Sean C. Elias, Samara Rosendo Machado, Julie Xiao, Lisa Schimanski, Victoria O’Dowd, Terry Baker, Emily Barry, Simon C. Mendelsohn, Catherine J. Cherry, Jing Jin, Geneviève M. Labbé, Francesca R. Donnellan, Tommy Rampling, Stuart Dowall, Emma Rayner, Stephen Findlay-Wilson, Miles Carroll, Jia Guo, Xiao-Ning Xu, Kuan-Ying A. Huang, Ayato Takada, Gillian Burgess, David McMillan, Andy Popplewell, Daniel J. Lightwood, Simon J. Draper, Alain R. Townsend
Published 2019-04-01

Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.

by Christopher J A Duncan, Susanne H Sheehy, Katie J Ewer, Alexander D Douglas, Katharine A Collins, Fenella D Halstead, Sean C Elias, Patrick J Lillie, Kelly Rausch, Joan Aebig, Kazutoyo Miura, Nick J Edwards, Ian D Poulton, Angela Hunt-Cooke, David W Porter, Fiona M Thompson, Ros Rowland, Simon J Draper, Sarah C Gilbert, Michael P Fay, Carole A Long, Daming Zhu, Yimin Wu, Laura B Martin, Charles F Anderson, Alison M Lawrie, Adrian V S Hill, Ruth D Ellis
Published 2011-01-01