Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.

by Iris Z Uras, Thomas List, Sebastian M B Nijman
Published 2012-01-01

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.

by Barbara Mair, Tomasz Konopka, Claudia Kerzendorfer, Katia Sleiman, Sejla Salic, Violeta Serra, Markus K Muellner, Vasiliki Theodorou, Sebastian M B Nijman
Published 2016-09-01

Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis.

by Andrea Perne, Markus K Muellner, Magdalena Steinrueck, Nils Craig-Mueller, Julia Mayerhofer, Ilse Schwarzinger, Mathew Sloane, Iris Z Uras, Gregor Hoermann, Sebastian M B Nijman, Matthias Mayerhofer
Published 2009-12-01

MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

by Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z. Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M. Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K. Muellner, Zsuzsanna Bago-Horvath, Eric B. Haura, Joanna I. Loizou, Sebastian M. B. Nijman
Published 2016-12-01