The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1

by Sergey A. Krupenko, Sergey A. Krupenko, David A. Horita
Published 2019-10-01

Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. “The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung...

by Sergey A. Krupenko, Jaspreet Sharma
Published 2021-04-01

Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.

by Baharan Fekry, Amin Esmaeilniakooshkghazi, Sergey A Krupenko, Natalia I Krupenko
Published 2016-01-01

A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization.

by Suchandra DebRoy, Inga I Kramarenko, Sampa Ghose, Natalia V Oleinik, Sergey A Krupenko, Natalia I Krupenko
Published 2013-01-01

Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

by Natalia I. Krupenko, Jaspreet Sharma, Peter Pediaditakis, Kristi L. Helke, Madeline S. Hall, Xiuxia Du, Susan Sumner, Sergey A. Krupenko
Published 2020-11-01

CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.

by Qasim A Khan, Peter Pediaditakis, Yuryi Malakhau, Amin Esmaeilniakooshkghazi, Zahra Ashkavand, Valentin Sereda, Natalia I Krupenko, Sergey A Krupenko
Published 2018-01-01

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis

by Natalia I. Krupenko, Jaspreet Sharma, Halle M. Fogle, Peter Pediaditakis, Kyle C. Strickland, Xiuxia Du, Kristi L. Helke, Susan Sumner, Sergey A. Krupenko
Published 2021-06-01

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

by Michael F. Coleman, Ciara H. O’Flanagan, Alexander J. Pfeil, Xuewen Chen, Jane B. Pearce, Susan Sumner, Sergey A. Krupenko, Stephen D. Hursting
Published 2021-05-01

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

by Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Zdzislaw M. Szulc, Kevin J. Knagge, David R. Kirchner, David A. Horita, Sergey A. Krupenko, Natalia I. Krupenko
Published 2018-10-01