The structural basis for promoter -35 element recognition by the group IV sigma factors.

by William J Lane, Seth A Darst
Published 2006-09-01

RNA-Seq reveals differential gene expression in Staphylococcus aureus with single-nucleotide resolution.

by Joseph Osmundson, Scott Dewell, Seth A Darst
Published 2013-01-01

TFIIB is only ∼9 Å away from the 5'-end of a trimeric RNA primer in a functional RNA polymerase II preinitiation complex.

by Matthew J Bick, Sohail Malik, Arkady Mustaev, Seth A Darst
Published 2015-01-01

Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures

by Elizabeth A. Hubin, Mirjana Lilic, Seth A. Darst, Elizabeth A. Campbell
Published 2017-07-01

Eliminating effects of particle adsorption to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO

by James Chen, Alex J. Noble, Jin Young Kang, Seth A. Darst
Published 2019-01-01

Structure of a bacterial RNA polymerase holoenzyme open promoter complex

by Brian Bae, Andrey Feklistov, Agnieszka Lass-Napiorkowska, Robert Landick, Seth A Darst
Published 2015-09-01

CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex

by Brian Bae, James Chen, Elizabeth Davis, Katherine Leon, Seth A Darst, Elizabeth A Campbell
Published 2015-09-01

Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.

by Natacha Opalka, Jesse Brown, William J Lane, Kelly-Anne F Twist, Robert Landick, Francisco J Asturias, Seth A Darst
Published 2010-09-01

Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts

by Hande Boyaci, James Chen, Mirjana Lilic, Margaret Palka, Rachel Anne Mooney, Robert Landick, Seth A Darst, Elizabeth A Campbell
Published 2018-02-01

E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

by James Chen, Saumya Gopalkrishnan, Courtney Chiu, Albert Y Chen, Elizabeth A Campbell, Richard L Gourse, Wilma Ross, Seth A Darst
Published 2019-12-01

Structural basis for transcription complex disruption by the Mfd translocase

by Jin Young Kang, Eliza Llewellyn, James Chen, Paul Dominic B Olinares, Joshua Brewer, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Published 2021-01-01

Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA

by Elizabeth A Hubin, Allison Fay, Catherine Xu, James M Bean, Ruth M Saecker, Michael S Glickman, Seth A Darst, Elizabeth A Campbell
Published 2017-01-01

Structural basis of transcription arrest by coliphage HK022 Nun in an Escherichia coli RNA polymerase elongation complex

by Jin Young Kang, Paul Dominic B Olinares, James Chen, Elizabeth A Campbell, Arkady Mustaev, Brian T Chait, Max E Gottesman, Seth A Darst
Published 2017-03-01

Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

by James Peek, Mirjana Lilic, Daniel Montiel, Aleksandr Milshteyn, Ian Woodworth, John B. Biggins, Melinda A. Ternei, Paula Y. Calle, Michael Danziger, Thulasi Warrier, Kohta Saito, Nathaniel Braffman, Allison Fay, Michael S. Glickman, Seth A. Darst, Elizabeth A. Campbell, Sean F. Brady
Published 2018-10-01