High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells

by Jidnyasa Ingale, Armando Stano, Javier Guenaga, Shailendra Kumar Sharma, David Nemazee, Michael B. Zwick, Richard T. Wyatt
Published 2016-05-01

Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design

by Shailendra Kumar Sharma, Natalia de Val, Shridhar Bale, Javier Guenaga, Karen Tran, Yu Feng, Viktoriya Dubrovskaya, Andrew B. Ward, Richard T. Wyatt
Published 2015-04-01

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

by Lifei Yang, Shailendra Kumar Sharma, Christopher Cottrell, Javier Guenaga, Karen Tran, Richard Wilson, Anna-Janina Behrens, Max Crispin, Max Crispin, Max Crispin, Natalia de Val, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt
Published 2018-07-01

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

by Anita Sarkar, Shridhar Bale, Anna-Janina Behrens, Sonu Kumar, Shailendra Kumar Sharma, Natalia de Val, Jesper Pallesen, Adriana Irimia, Devan C. Diwanji, Robyn L. Stanfield, Andrew B. Ward, Max Crispin, Richard T. Wyatt, Ian A. Wilson
Published 2018-05-01