The B-cell specific transcription factor, Oct-2, promotes Epstein-Barr virus latency by inhibiting the viral immediate-early protein, BZLF1.

by Amanda R Robinson, Swee Sen Kwek, Shannon C Kenney
Published 2012-02-01

Methylation-dependent binding of the epstein-barr virus BZLF1 protein to viral promoters.

by Sarah J Dickerson, Yongna Xing, Amanda R Robinson, William T Seaman, Henri Gruffat, Shannon C Kenney
Published 2009-03-01

Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells.

by Nicholas Van Sciver, Makoto Ohashi, Nicholas P Pauly, Jillian A Bristol, Scott E Nelson, Eric C Johannsen, Shannon C Kenney
Published 2021-08-01

PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model.

by Shi-Dong Ma, Xuequn Xu, Richard Jones, Henri-Jacques Delecluse, Nicholas A Zumwalde, Akshat Sharma, Jenny E Gumperz, Shannon C Kenney
Published 2016-05-01

An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model.

by James C Romero-Masters, Makoto Ohashi, Reza Djavadian, Mark R Eichelberg, Mitch Hayes, Jillian A Bristol, Shidong Ma, Erik A Ranheim, Jenny Gumperz, Eric C Johannsen, Shannon C Kenney
Published 2018-08-01

Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from the Cell Cycle

by Mark R. Eichelberg, Rene Welch, J. Tod Guidry, Ahmed Ali, Makoto Ohashi, Kathleen R. Makielski, Kyle McChesney, Nicholas Van Sciver, Paul F. Lambert, Sündüz Keleș, Shannon C. Kenney, Rona S. Scott, Eric Johannsen
Published 2019-08-01

EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mi...

by Chunrong Li, James C Romero-Masters, Shane Huebner, Makoto Ohashi, Mitchell Hayes, Jillian A Bristol, Scott E Nelson, Mark R Eichelberg, Nicholas Van Sciver, Erik A Ranheim, Rona S Scott, Eric C Johannsen, Shannon C Kenney
Published 2020-06-01

A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection.

by Jillian A Bristol, Reza Djavadian, Emily R Albright, Carrie B Coleman, Makoto Ohashi, Mitchell Hayes, James C Romero-Masters, Elizabeth A Barlow, Paul J Farrell, Rosemary Rochford, Robert F Kalejta, Eric C Johannsen, Shannon C Kenney
Published 2018-07-01

Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells.

by Dhananjay M Nawandar, Anqi Wang, Kathleen Makielski, Denis Lee, Shidong Ma, Elizabeth Barlow, Jessica Reusch, Ru Jiang, Coral K Wille, Deborah Greenspan, John S Greenspan, Janet E Mertz, Lindsey Hutt-Fletcher, Eric C Johannsen, Paul F Lambert, Shannon C Kenney
Published 2015-10-01

B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection.

by James C Romero-Masters, Shane M Huebner, Makoto Ohashi, Jillian A Bristol, Bayleigh E Benner, Elizabeth A Barlow, Gail L Turk, Scott E Nelson, Dana C Baiu, Nicholas Van Sciver, Erik A Ranheim, Jenny Gumperz, Nathan M Sherer, Paul J Farrell, Eric C Johannsen, Shannon C Kenney
Published 2020-02-01

Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1...

by Richard J Kraus, Xianming Yu, Blue-Leaf A Cordes, Saraniya Sathiamoorthi, Tawin Iempridee, Dhananjay M Nawandar, Shidong Ma, James C Romero-Masters, Kyle G McChesney, Zhen Lin, Kathleen R Makielski, Denis L Lee, Paul F Lambert, Eric C Johannsen, Shannon C Kenney, Janet E Mertz
Published 2017-06-01