Searching for the real function of mTOR signaling in the regulation of PD-L1 expression

by Shi-Yong Sun
Published 2020-12-01

Regulation of Cancer Metastasis by TRAIL/Death Receptor Signaling

by You-Take Oh, Shi-Yong Sun
Published 2021-03-01

DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion

by You-Take Oh, Ping Yue, Shi-Yong Sun
Published 2017-05-01

MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer

by Qiming Wang, Sen Yang, Kai Wang, Shi-Yong Sun
Published 2019-06-01

Inhibition of p70S6K does not mimic the enhancement of Akt phosphorylation by rapamycin

by Xuerong Wang, Ping Yue, Hui Tao, Shi-Yong Sun
Published 2017-08-01

The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5

by You-Take Oh, Liang Deng, Jiusheng Deng, Shi-Yong Sun
Published 2017-08-01

MET inhibition downregulates DR4 expression in MET-amplified lung cancer cells with acquired resistance to EGFR inhibitors through suppressing AP-1-mediated transcription

by Liang Deng, Karin A. Vallega, Shuo Zhang, Puyu Shi, Shi-Yong Sun
Published 2021-08-01

Mono- or double-site phosphorylation distinctly regulates the proapoptotic function of Bax.

by Qinhong Wang, Shi-Yong Sun, Fadlo Khuri, Walter J Curran, Xingming Deng
Published 2010-10-01

The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein T...

by Songqing Fan, Yikun Li, Ping Yue, Fadlo R. Khuri, Shi-Yong Sun
Published 2010-04-01

Pan-cancer analysis of pathway-based gene expression pattern at the individual level reveals biomarkers of clinical prognosis

by Kenong Su, Qi Yu, Ronglai Shen, Shi-Yong Sun, Carlos S. Moreno, Xiaoxian Li, Zhaohui S. Qin
Published 2021-08-01

Overcoming acquired resistance of EGFR‐mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib, with the natural product honokiol

by Hongjing Zang, Guoqing Qian, Jack Arbiser, Taofeek K. Owonikoko, Suresh S. Ramalingam, Songqing Fan, Shi‐Yong Sun
Published 2020-04-01

c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.

by John Kauh, Songqing Fan, Mingjing Xia, Ping Yue, Lily Yang, Fadlo R Khuri, Shi-Yong Sun
Published 2010-01-01

Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E

by Yikun Li, Ping Yue, Xingming Deng, Takeshi Ueda, Rikiro Fukunaga, Fadlo R. Khuri, Shi-Yong Sun
Published 2010-10-01

The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations

by Puyu Shi, Shuo Zhang, Lei Zhu, Guoqing Qian, Hui Ren, Suresh S. Ramalingam, Mingwei Chen, Shi-Yong Sun
Published 2019-05-01

The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivo.

by Cheng-Xiong Xu, Yikun Li, Ping Yue, Taofeek K Owonikoko, Suresh S Ramalingam, Fadlo R Khuri, Shi-Yong Sun
Published 2011-01-01

Evaluation of preclinical efficacy of everolimus and pasireotide in thyroid cancer cell lines and xenograft models.

by Taofeek K Owonikoko, Guojing Zhang, Shenila B Lallani, Zhengjia Chen, Deborah E Martinson, Fadlo R Khuri, Sagar Lonial, Adam Marcus, Shi-Yong Sun
Published 2019-01-01

Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact.

by Heath A Elrod, Songqing Fan, Susan Muller, Georgia Z Chen, Lin Pan, Mourad Tighiouart, Dong M Shin, Fadlo R Khuri, Shi-Yong Sun
Published 2010-08-01

GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis

by Jian Wang, Alton B. Farris, Kaiming Xu, Ping Wang, Xiangming Zhang, Duc M. Duong, Hong Yi, Hui-Kuo Shu, Shi-Yong Sun, Ya Wang
Published 2016-06-01

c-Myc Suppression of DNA Double-strand Break Repair

by Zhaozhong Li, Taofeek K. Owonikoko, Shi-Yong Sun, Suresh S. Ramalingam, Paul W. Doetsch, Zhi-Qiang Xiao, Fadlo R. Khuri, Walter J. Curran, Xingming Deng
Published 2012-12-01