Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance

by Dorota Kmiec, Shilpa S. Iyer, Christina M. Sturzel, Daniel Sauter, Beatrice H. Hahn, Frank Kirchhoff
Published 2016-08-01

A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1.

by Simon M Langer, Kristina Hopfensperger, Shilpa S Iyer, Edward F Kreider, Gerald H Learn, Lan-Hui Lee, Beatrice H Hahn, Daniel Sauter
Published 2015-01-01

Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus.

by Hongshuo Song, Bhavna Hora, Tanmoy Bhattacharya, Nilu Goonetilleke, Michael K P Liu, Kevin Wiehe, Hui Li, Shilpa S Iyer, Andrew J McMichael, Alan S Perelson, Feng Gao
Published 2014-01-01

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape.

by Katharine J Bar, Chun-yen Tsao, Shilpa S Iyer, Julie M Decker, Yongping Yang, Mattia Bonsignori, Xi Chen, Kwan-Ki Hwang, David C Montefiori, Hua-Xin Liao, Peter Hraber, William Fischer, Hui Li, Shuyi Wang, Sarah Sterrett, Brandon F Keele, Vitaly V Ganusov, Alan S Perelson, Bette T Korber, Ivelin Georgiev, Jason S McLellan, Jeffrey W Pavlicek, Feng Gao, Barton F Haynes, Beatrice H Hahn, Peter D Kwong, George M Shaw
Published 2012-01-01

Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.

by Nicholas F Parrish, Craig B Wilen, Lauren B Banks, Shilpa S Iyer, Jennifer M Pfaff, Jesus F Salazar-Gonzalez, Maria G Salazar, Julie M Decker, Erica H Parrish, Anna Berg, Jennifer Hopper, Bhavna Hora, Amit Kumar, Tatenda Mahlokozera, Sally Yuan, Charl Coleman, Marion Vermeulen, Haitao Ding, Christina Ochsenbauer, John C Tilton, Sallie R Permar, John C Kappes, Michael R Betts, Michael P Busch, Feng Gao, David Montefiori, Barton F Haynes, George M Shaw, Beatrice H Hahn, Robert W Doms
Published 2012-01-01