The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes.

by Takashi Shibano, Hiroshi Mamada, Fumihiko Hakuno, Shin-Ichiro Takahashi, Masanori Taira
Published 2015-01-01

Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation

by Ryosuke Okino, Ami Usui, Yosuke Yoneyama, Shin-Ichiro Takahashi, Fumihiko Hakuno, Fumihiko Hakuno
Published 2020-02-01

A novel amino acid signaling process governs glucose-6-phosphatase transcription

by Sara Fukushima, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
Published 2021-07-01

Alteration of serum amino acid profiles by dietary adenine supplementation inhibits fatty liver development in rats

by Hiroki Nishi, Daisuke Yamanaka, Masato Masuda, Yuki Goda, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
Published 2020-12-01

Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver

by Shin-Ichi Yokota, Kaai Nakamura, Midori Ando, Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shigenobu Shibata
Published 2014-01-01

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase

by Yosuke Yoneyama, Tomomi Inamitsu, Kazuhiro Chida, Shun-Ichiro Iemura, Tohru Natsume, Tatsuya Maeda, Fumihiko Hakuno, Shin-Ichiro Takahashi
Published 2018-07-01

Phosphatidylinositol 3-kinase-associated protein (PI3KAP)/XB130 crosslinks actin filaments through its actin binding and multimerization properties in vitro and enhances endocytosi...

by Daisuke Yamanaka, Daisuke Yamanaka, Daisuke Yamanaka, Takeshi Akama, Kazuhiro Chida, Shiro Minami, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
Published 2016-07-01

The Short-Stature Homeobox-Containing Gene (shox/SHOX) Is Required for the Regulation of Cell Proliferation and Bone Differentiation in Zebrafish Embryo and Human Mesenchymal Stem...

by Tomoaki Yokokura, Tomoaki Yokokura, Tomoaki Yokokura, Hiroyasu Kamei, Hiroyasu Kamei, Hiroyasu Kamei, Takashi Shibano, Takashi Shibano, Takashi Shibano, Daisuke Yamanaka, Daisuke Yamanaka, Daisuke Yamanaka, Rie Sawada-Yamaguchi, Rie Sawada-Yamaguchi, Rie Sawada-Yamaguchi, Fumihiko Hakuno, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shin-Ichiro Takahashi, Toshiaki Shimizu
Published 2017-06-01

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

by Yosuke Yoneyama, Peter Lanzerstorfer, Hideaki Niwa, Takashi Umehara, Takashi Shibano, Shigeyuki Yokoyama, Kazuhiro Chida, Julian Weghuber, Fumihiko Hakuno, Shin-Ichiro Takahashi
Published 2018-04-01

Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts.

by Fumihiko Hakuno, Yoko Yamauchi, Gen Kaneko, Yosuke Yoneyama, Jun Nakae, Kazuhiro Chida, Tatsuhiko Kadowaki, Keitaro Yamanouchi, Masugi Nishihara, Shin-Ichiro Takahashi
Published 2011-01-01

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

by Ambika Krishnankutty, Taeko Kimura, Taro Saito, Kyota Aoyagi, Akiko Asada, Shin-Ichiro Takahashi, Kanae Ando, Mica Ohara-Imaizumi, Koichi Ishiguro, Shin-ichi Hisanaga
Published 2017-08-01

Low-arginine and low-protein diets induce hepatic lipid accumulation through different mechanisms in growing rats

by Lila Otani, Hiroki Nishi, Ayaka Koyama, Yuta Akasaka, Yusuke Taguchi, Yuka Toyoshima, Daisuke Yamanaka, Fumihiko Hakuno, Huijuan Jia, Shin-Ichiro Takahashi, Hisanori Kato
Published 2020-08-01

Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences

by So Masaki, So Masaki, Shun Ikeda, Asuka Hata, Yusuke Shiozawa, Ayana Kon, Seishi Ogawa, Kenji Suzuki, Fumihiko Hakuno, Shin-Ichiro Takahashi, Naoyuki Kataoka, Naoyuki Kataoka
Published 2019-04-01

Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats

by Mami Horiuchi, Tomoya Takeda, Hiroyuki Takanashi, Yori Ozaki-Masuzawa, Yusuke Taguchi, Yuka Toyoshima, Lila Otani, Hisanori Kato, Meri Sone-Yonezawa, Fumihiko Hakuno, Shin-Ichiro Takahashi, Asako Takenaka
Published 2017-09-01

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis

by Yasuka Matsunaga, Yusuke Nakatsu, Toshiaki Fukushima, Hirofumi Okubo, Misaki Iwashita, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, Akifumi Kushiyama, Shin-ichiro Takahashi, Yoshihiro Tsuchiya, Hideaki Kamata, Fuminori Tokunaga, Kazuhiro Iwai, Tomoichiro Asano
Published 2015-01-01

Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Hum...

by Dan O. Wang, Dan O. Wang, Kensuke Ninomiya, Kensuke Ninomiya, Chihiro Mori, Ayako Koyama, Martine Haan, Makoto Kitabatake, Masatoshi Hagiwara, Kazuhiro Chida, Shin-Ichiro Takahashi, Mutsuhito Ohno, Naoyuki Kataoka, Naoyuki Kataoka, Naoyuki Kataoka, Naoyuki Kataoka, Naoyuki Kataoka
Published 2017-12-01

Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

by Mimin Zhang, Peng Lu, Tohru Terada, Miaomiao Sui, Haruka Furuta, Kilico Iida, Yukie Katayama, Yi Lu, Ken Okamoto, Michio Suzuki, Tomiko Asakura, Kentaro Shimizu, Fumihiko Hakuno, Shin-Ichiro Takahashi, Norimoto Shimada, Jinwei Yang, Tsutomu Ishikawa, Jin Tatsuzaki, Koji Nagata
Published 2021-02-01

Rapid manipulation of mitochondrial morphology in a living cell with iCMM

by Takafumi Miyamoto, Hideki Uosaki, Yuhei Mizunoe, Song-Iee Han, Satoi Goto, Daisuke Yamanaka, Masato Masuda, Yosuke Yoneyama, Hideki Nakamura, Naoko Hattori, Yoshinori Takeuchi, Hiroshi Ohno, Motohiro Sekiya, Takashi Matsuzaka, Fumihiko Hakuno, Shin-Ichiro Takahashi, Naoya Yahagi, Koichi Ito, Hitoshi Shimano
Published 2021-08-01

Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16

by Yusuke Nakatsu, Yasuka Matsunaga, Takeshi Yamamotoya, Koji Ueda, Masa-ki Inoue, Yu Mizuno, Mikako Nakanishi, Tomomi Sano, Yosuke Yamawaki, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Akihide Ryo, Hiraku Ono, Tohru Minamino, Shin-Ichiro Takahashi, Haruya Ohno, Masayasu Yoneda, Kei Takahashi, Hisamitsu Ishihara, Hideki Katagiri, Fusanori Nishimura, Takashi Kanematsu, Tetsuya Yamada, Tomoichiro Asano
Published 2019-03-01