Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells

by Ying Wang, Siegfried Hekimi
Published 2021-08-01

A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.

by Wen Yang, Siegfried Hekimi
Published 2010-12-01

Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations

by Ying Wang, Siegfried Hekimi
Published 2020-09-01

A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice.

by Bryan G Hughes, Siegfried Hekimi
Published 2011-01-01

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.

by Jeremy M Van Raamsdonk, Siegfried Hekimi
Published 2009-02-01

Mitochondrial ROS and the effectors of the intrinsic apoptotic pathway in aging cells: the discerning killers!

by Siegfried Hekimi, Ying Wang, Alycia Noe
Published 2016-09-01

A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1

by Ju-Ling Liu, Callista Yee, Ying Wang, Siegfried Hekimi
Published 2017-04-01

Mitochondrial oxidative stress alters a pathway in Caenorhabditis elegans strongly resembling that of bile acid biosynthesis and secretion in vertebrates.

by Ju-Ling Liu, David Desjardins, Robyn Branicky, Luis B Agellon, Siegfried Hekimi
Published 2012-01-01

An enhanced immune response of Mclk1⁺/⁻ mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging.

by Dantong Wang, Ying Wang, Catherine Argyriou, Audrey Carrière, Danielle Malo, Siegfried Hekimi
Published 2012-01-01

Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans.

by Cassandra R Blanchette, Andrea Thackeray, Paola N Perrat, Siegfried Hekimi, Claire Y Bénard
Published 2017-01-01

ROS regulation of RAS and vulva development in Caenorhabditis elegans.

by Maximilian Kramer-Drauberg, Ju-Ling Liu, David Desjardins, Ying Wang, Robyn Branicky, Siegfried Hekimi
Published 2020-06-01

Mitochondrial and cytoplasmic ROS have opposing effects on lifespan.

by Claire E Schaar, Dylan J Dues, Katie K Spielbauer, Emily Machiela, Jason F Cooper, Megan Senchuk, Siegfried Hekimi, Jeremy M Van Raamsdonk
Published 2015-02-01

CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants.

by Aiswarya Baruah, Hsinwen Chang, Mathew Hall, Jie Yuan, Sarah Gordon, Erik Johnson, Ludmila L Shtessel, Callista Yee, Siegfried Hekimi, W Brent Derry, Siu Sylvia Lee
Published 2014-02-01

Evolutionary conservation of drug action on lipoprotein metabolism-related targetss⃞

by Abdelmadjid K. Hihi, Marie-Claude Beauchamp, Robyn Branicky, Annick Desjardins, Isabel Casanova, Marie-Pierre Guimond, Melissa Carroll, Melanie Ethier, Irenej Kianicka, Kevin McBride, Siegfried Hekimi
Published 2008-01-01

Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.

by Vlad C Seitan, Peter Banks, Steve Laval, Nazia A Majid, Dale Dorsett, Amer Rana, Jim Smith, Alex Bateman, Sanja Krpic, Arnd Hostert, Robert A Rollins, Hediye Erdjument-Bromage, Paul Tempst, Claire Y Benard, Siegfried Hekimi, Sarah F Newbury, Tom Strachan
Published 2006-07-01

Studies of aging, metabolism and the age-dependent disease atherosclerosis in mouse mutants with altered mitochondrial function

by Hughes, Bryan
Published 2011

Mitochondrial function in cells, tissues and animals without ubiquinone biosynthesis

by Wang, Ying
Published 2014

Genetic interactions between suppressors of the slow defecation of phenotype of clk-1 mutants

by Kryzskaya, Darya
Published 2012

Mitochondrial dysfunction and reactive oxygen species metabolism in the aging process of «Caenorhabditis elegans»

by Yang, Wen
Published 2010

A conserved bile acid biosynthesis and secretion pathway in Caenorhabditis elegans

by Liu, Ju-Ling
Published 2013