High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs

by Sylvia Merkert, Madline Schubert, Ruth Olmer, Lena Engels, Silke Radetzki, Mieke Veltman, Bob J. Scholte, Janina Zöllner, Nicoletta Pedemonte, Luis J.V. Galietta, Jens P. von Kries, Ulrich Martin
Published 2019-06-01

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

by Hanna Bonnekoh, Carolina Vera, Angela Abad‐Perez, Silke Radetzki, Martin Neuenschwander, Edgar Specker, Niklas Amadeus Mahnke, Stefan Frischbutter, Eicke Latz, Marc Nazaré, Jens v. Kries, Marcus Maurer, Jörg Scheffel, Karoline Krause
Published 2021-07-01

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.

by Manisha Juneja, Dennis Kobelt, Wolfgang Walther, Cynthia Voss, Janice Smith, Edgar Specker, Martin Neuenschwander, Björn-Oliver Gohlke, Mathias Dahlmann, Silke Radetzki, Robert Preissner, Jens Peter von Kries, Peter Michael Schlag, Ulrike Stein
Published 2017-06-01

A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation

by Jenny Ostrop, Rosalie T. Zwiggelaar, Marianne Terndrup Pedersen, Marianne Terndrup Pedersen, François Gerbe, Korbinian Bösl, Håvard T. Lindholm, Alberto Díez-Sánchez, Naveen Parmar, Silke Radetzki, Jens Peter von Kries, Philippe Jay, Kim B. Jensen, Kim B. Jensen, Cheryl Arrowsmith, Cheryl Arrowsmith, Cheryl Arrowsmith, Menno J. Oudhoff
Published 2021-01-01

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

by Cécile Otten, Jessica Knox, Gwénola Boulday, Mathias Eymery, Marta Haniszewski, Martin Neuenschwander, Silke Radetzki, Ingo Vogt, Kristina Hähn, Coralie De Luca, Cécile Cardoso, Sabri Hamad, Carla Igual Gil, Peter Roy, Corinne Albiges‐Rizo, Eva Faurobert, Jens P vonKries, Mónica Campillos, Elisabeth Tournier‐Lasserve, W Brent Derry, Salim Abdelilah‐Seyfried
Published 2018-10-01