2-(2-Methyl-2-nitrovinyl)furan but Not Furvina Interfere with <i>Staphylococcus aureus</i> Agr Quorum-Sensing System and Potentiate the Action of Fusidic Acid against Biofilms

by Diana Oliveira, Anabela Borges, Reinaldo Molina Ruiz, Zenaida Rodríguez Negrín, Simona Distinto, Fernanda Borges, Manuel Simões
Published 2021-01-01

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase

by Rita Meleddu, Simona Distinto, Angela Corona, Enzo Tramontano, Giulia Bianco, Claudia Melis, Filippo Cottiglia, Elias Maccioni
Published 2017-01-01

Structure-Based Virtual Screening of Novel Natural Alkaloid Derivatives as Potential Binders of h-telo and c-myc DNA G-Quadruplex Conformations

by Roberta Rocca, Federica Moraca, Giosuè Costa, Stefano Alcaro, Simona Distinto, Elias Maccioni, Francesco Ortuso, Anna Artese, Lucia Parrotta
Published 2014-12-01

Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H funct...

by Benedetta Fois, Angela Corona, Enzo Tramontano, Simona Distinto, Elias Maccioni, Rita Meleddu, Pierluigi Caboni, Costantino Floris, Filippo Cottiglia
Published 2021-01-01

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

by Claudia Melis, Rita Meleddu, Andrea Angeli, Simona Distinto, Giulia Bianco, Clemente Capasso, Filippo Cottiglia, Rossella Angius, Claudiu T. Supuran, Elias Maccioni
Published 2017-01-01

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

by Rita Meleddu, Simona Distinto, Roberto Cirilli, Stefano Alcaro, Matilde Yanez, Maria Luisa Sanna, Angela Corona, Claudia Melis, Giulia Bianco, Peter Matyus, Filippo Cottiglia, Elias Maccioni
Published 2017-01-01

Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

by Benedetta Fois, Simona Distinto, Rita Meleddu, Serenella Deplano, Elias Maccioni, Costantino Floris, Antonella Rosa, Mariella Nieddu, Pierluigi Caboni, Claudia Sissi, Andrea Angeli, Claudiu T. Supuran, Filippo Cottiglia
Published 2020-01-01

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives

by Rita Meleddu, Serenella Deplano, Elias Maccioni, Francesco Ortuso, Filippo Cottiglia, Daniela Secci, Alessia Onali, Erica Sanna, Andrea Angeli, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Simona Distinto
Published 2021-01-01

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

by Serena Massari, Angela Corona, Simona Distinto, Jenny Desantis, Alessia Caredda, Stefano Sabatini, Giuseppe Manfroni, Tommaso Felicetti, Violetta Cecchetti, Christophe Pannecouque, Elias Maccioni, Enzo Tramontano, Oriana Tabarrini
Published 2019-01-01

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6.

by Angela Corona, Rita Meleddu, Francesca Esposito, Simona Distinto, Giulia Bianco, Takashi Masaoka, Elias Maccioni, Luis Menéndez-Arias, Stefano Alcaro, Stuart F J Le Grice, Enzo Tramontano
Published 2016-01-01

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

by Simona Distinto, Rita Meleddu, Francesco Ortuso, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Claudia Melis, Benedetta Fois, Andrea Angeli, Clemente Capasso, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni
Published 2019-01-01

Targeting HIV-1 RNase H: <i>N’</i>-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants

by Angela Corona, Ester Ballana, Simona Distinto, Dominga Rogolino, Claudia Del Vecchio, Mauro Carcelli, Roger Badia, Eva Riveira-Muñoz, Francesca Esposito, Cristina Parolin, José A. Esté, Nicole Grandi, Enzo Tramontano
Published 2020-07-01

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

by Rita Meleddu, Angela Corona, Simona Distinto, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Daniela Secci, Alessia Onali, Erica Sanna, Francesca Esposito, Italo Cirone, Francesco Ortuso, Stefano Alcaro, Enzo Tramontano, Péter Mátyus, Elias Maccioni
Published 2021-06-01