Unanchored Ubiquitin Chains, Revisited

by Jessica R. Blount, Sean L. Johnson, Sokol V. Todi, Sokol V. Todi
Published 2020-10-01

An Optimal Ubiquitin-Proteasome Pathway in the Nervous System: The Role of Deubiquitinating Enzymes

by Gorica eRistic, Wei-Ling eTsou, Sokol V Todi
Published 2014-08-01

Toxicity and aggregation of the polyglutamine disease protein, ataxin-3 is regulated by its binding to VCP/p97 in Drosophila melanogaster

by Gorica Ristic, Joanna R. Sutton, Kozeta Libohova, Sokol V. Todi
Published 2018-08-01

Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations.

by Alyson Sujkowski, Anna Gretzinger, Nicolette Soave, Sokol V Todi, Robert Wessells
Published 2020-06-01

Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling

by Jessica R. Blount, Kozeta Libohova, Gustavo M. Silva, Sokol V. Todi
Published 2020-06-01

Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation

by Sean L Johnson, Bedri Ranxhi, Kozeta Libohova, Wei-Ling Tsou, Sokol V Todi
Published 2020-09-01

Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation.

by Jessica R Blount, Aaron A Burr, Amanda Denuc, Gemma Marfany, Sokol V Todi
Published 2012-01-01

Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development.

by Sokol V Todi, Elena Sivan-Loukianova, Julie S Jacobs, Daniel P Kiehart, Daniel F Eberl
Published 2008-05-01

Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson’s disease with dementi...

by Deepthi Yedlapudi, Liping Xu, Dan Luo, Gregory B. Marsh, Sokol V. Todi, Aloke K. Dutta
Published 2019-12-01

Polyglutamine length-dependent toxicity from α1ACT in Drosophila models of spinocerebellar ataxia type 6

by Wei-Ling Tsou, Sultan H. Qiblawi, Ryan R. Hosking, Christopher M. Gomez, Sokol V. Todi
Published 2016-12-01

Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.

by Giuseppe Nicastro, Sokol V Todi, Ezgi Karaca, Alexandre M J J Bonvin, Henry L Paulson, Annalisa Pastore
Published 2010-08-01

Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3

by Sean L. Johnson, Jessica R. Blount, Kozeta Libohova, Bedri Ranxhi, Henry L. Paulson, Wei-Ling Tsou, Sokol V. Todi
Published 2019-12-01

Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster

by Jessica R. Blount, Danielle N. Meyer, Camille Akemann, Sean L. Johnson, Katherine Gurdziel, Tracie R. Baker, Sokol V. Todi
Published 2019-05-01

Opioid Deaths: Trends, Biomarkers, and Potential Drug Interactions Revealed by Decision Tree Analyses

by Manal H. Saad, Candace L. Savonen, Matthew Rumschlag, Sokol V. Todi, Carl J. Schmidt, Carl J. Schmidt, Michael J. Bannon
Published 2018-10-01

Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3

by Sean L. Johnson, Kozeta Libohova, Jessica R. Blount, Alyson L. Sujkowski, Matthew V. Prifti, Wei-Ling Tsou, Sokol V. Todi
Published 2021-12-01

The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster

by Wei-Ling Tsou, Michelle Ouyang, Ryan R. Hosking, Joanna R. Sutton, Jessica R. Blount, Aaron A. Burr, Sokol V. Todi
Published 2015-10-01

Systematic analysis of the physiological importance of deubiquitinating enzymes.

by Wei-Ling Tsou, Michael J Sheedlo, Marie E Morrow, Jessica R Blount, Kelly M McGregor, Chittaranjan Das, Sokol V Todi
Published 2012-01-01

Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein

by Naila S. Ashraf, Joanna R. Sutton, Yemen Yang, Bedri Ranxhi, Kozeta Libohova, Emily D. Shaw, Anna J. Barget, Sokol V. Todi, Henry L. Paulson, Maria do Carmo Costa
Published 2020-04-01

Allosteric regulation of deubiquitylase activity through ubiquitination

by Serena eFaggiano, Rajesh P. Menon, Geoff P. Kelly, Sokol V. Todi, K. Matthew Scaglione, Petr V. Konarev, Petr V. Konarev, Dmitri I. Svergun, Henry L. Paulson, Annalisa ePastore
Published 2015-02-01