Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity.

by Rashika El Ridi, Hatem Tallima, Sahar Selim, Sheila Donnelly, Sophie Cotton, Bibiana Gonzales Santana, John P Dalton
Published 2014-01-01

Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation.

by Karine Thivierge, Sophie Cotton, Deborah A Schaefer, Michael W Riggs, Joyce To, Maria E Lund, Mark W Robinson, John P Dalton, Sheila M Donnelly
Published 2013-01-01

Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs).

by Jenna Shiels, Krystyna Cwiklinski, Raquel Alvarado, Karine Thivierge, Sophie Cotton, Bibiana Gonzales Santana, Joyce To, Sheila Donnelly, Clifford C Taggart, Sinead Weldon, John P Dalton
Published 2020-07-01

Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases

by Karine Thivierge, Rency T. Mathew, Desire M. M. Nsangou, Fabio Da Silva, Sophie Cotton, Tina S. Skinner-Adams, Katharine R. Trenholme, Christopher L. Brown, Colin M. Stack, Donald L. Gardiner, John P. Dalton
Published 2012-06-01