Why is a functional PHO pathway required by fungal pathogens to disseminate within a phosphate-rich host: A paradox explained by alkaline pH-simulated nutrient deprivation and expa...

by Sophie Lev, Julianne Teresa Djordjevic
Published 2018-06-01

Oxidant-Sensing Pathways in the Responses of Fungal Pathogens to Chemical Stress Signals

by Hiba Simaan, Sophie Lev, Benjamin A. Horwitz
Published 2019-03-01

Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Cryptococcus neoformans Present Novel Drug Targeting Op...

by Sophie Lev, Sophie Lev, Sophie Lev, Cecilia Li, Cecilia Li, Desmarini Desmarini, Desmarini Desmarini, Desmarini Desmarini, Tania C. Sorrell, Tania C. Sorrell, Tania C. Sorrell, Adolfo Saiardi, Julianne T. Djordjevic, Julianne T. Djordjevic, Julianne T. Djordjevic
Published 2019-07-01

The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity.

by Sophie Lev, Desmarini Desmarini, Methee Chayakulkeeree, Tania C Sorrell, Julianne T Djordjevic
Published 2012-01-01

Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery

by Cecilia Li, Sophie Lev, Adolfo Saiardi, Desmarini Desmarini, Tania C. Sorrell, Julianne T. Djordjevic
Published 2016-09-01

Monitoring Glycolysis and Respiration Highlights Metabolic Inflexibility of <i>Cryptococcus neoformans</i>

by Sophie Lev, Cecilia Li, Desmarini Desmarini, David Liuwantara, Tania C. Sorrell, Wayne J. Hawthorne, Julianne T. Djordjevic
Published 2020-08-01

The PHO signaling pathway directs lipid remodeling in Cryptococcus neoformans via DGTS synthase to recycle phosphate during phosphate deficiency.

by Sophie Lev, Thusitha Rupasinghe, Desmarini Desmarini, Keren Kaufman-Francis, Tania Christine Sorrell, Ute Roessner, Julianne Teresa Djordjevic
Published 2019-01-01

Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH

by Sophie Lev, Keren Kaufman-Francis, Desmarini Desmarini, Pierre G. Juillard, Cecilia Li, Sebastian A. Stifter, Carl G. Feng, Tania C. Sorrell, Georges E. R. Grau, Yong-Sun Bahn, Julianne T. Djordjevic, Aaron P. Mitchell
Published 2017-01-01