The burden of trisomy 21 disrupts the proteostasis network in Down syndrome.

by Stefanos Aivazidis, Christina M Coughlan, Abhishek K Rauniyar, Hua Jiang, L Alexander Liggett, Kenneth N Maclean, James R Roede
Published 2017-01-01

SNARE proteins rescue impaired autophagic flux in Down syndrome.

by Stefanos Aivazidis, Abhilasha Jain, Abhishek K Rauniyar, Colin C Anderson, John O Marentette, David J Orlicky, Kristofer S Fritz, Peter S Harris, David Siegel, Kenneth N Maclean, James R Roede
Published 2019-01-01

Neuron-specific mitochondrial oxidative stress results in epilepsy, glucose dysregulation and a striking astrocyte response

by Ruth E. Fulton, Jennifer N. Pearson-Smith, Christopher Q. Huynh, Timothy Fabisiak, Li-Ping Liang, Stefanos Aivazidis, Brigit A. High, Georgia Buscaglia, Timothy Corrigan, Robert Valdez, Takahiko Shimizu, Manisha N. Patel
Published 2021-10-01