The Gut Hormones in Appetite Regulation

by Keisuke Suzuki, Channa N. Jayasena, Stephen R. Bloom
Published 2011-01-01

No Guts, No Loss: Toward the Ideal Treatment for Obesity in the Twenty-First Century

by David C. D. Hope, Tricia M. M. Tan, Stephen R. Bloom
Published 2018-08-01

Investigating the Glucagon Receptor and Glucagon-Like Peptide 1 Receptor Activity of Oxyntomodulin-Like Analogues in Male Wistar Rats

by Samantha L. Price, MRes, James S. Minnion, PhD, Stephen R. Bloom, MD
Published 2015-12-01

Quantification of rat kisspeptin using a novel radioimmunoassay.

by James S Kinsey-Jones, Kylie E Beale, Joy Cuenco, Xiao Feng Li, Stephen R Bloom, Kevin T O'Byrne, Kevin G Murphy
Published 2014-01-01

Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

by Emma Rose McGlone, Yusman Manchanda, Ben Jones, Phil Pickford, Asuka Inoue, David Carling, Stephen R. Bloom, Tricia Tan, Alejandra Tomas
Published 2021-11-01

Substance P immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region.

by Erik Hrabovszky, Beáta Á Borsay, Kálmán Rácz, László Herczeg, Philippe Ciofi, Stephen R Bloom, Mohammad A Ghatei, Waljit S Dhillo, Zsolt Liposits
Published 2013-01-01

Colocalization of cocaine- and amphetamine-regulated transcript with kisspeptin and neurokinin B in the human infundibular region.

by Katalin Skrapits, Beáta Á Borsay, László Herczeg, Philippe Ciofi, Stephen R Bloom, Mohammad A Ghatei, Waljit S Dhillo, Zsolt Liposits, Erik Hrabovszky
Published 2014-01-01

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

by Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Published 2020-07-01

The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

by Sagen Zac-Varghese, Stefan Trapp, Paul Richards, Sophie Sayers, Gao Sun, Stephen R. Bloom, Frank Reimann, Fiona M. Gribble, Guy A. Rutter
Published 2014-11-01

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

by Sophie R Sayers, Frank Reimann, Fiona M Gribble, Helen Parker, Sagen Zac-Varghese, Stephen R Bloom, Marc Foretz, Benoit Viollet, Guy A Rutter
Published 2016-01-01

Proglucagon peptide secretion profiles in type 2 diabetes before and after bariatric surgery: 1-year prospective study

by Kleopatra Alexiadou, Joyceline Cuenco, Nicolai Jacob Wewer Albrechtsen, Ibiyemi Ilesanmi, Anna Kamocka, George Tharakan, Preeshila Behary, Paul R Bech, Ahmed R Ahmed, Sanjay Purkayastha, Robert Wheller, Matthieu Fleuret, Stephen R Bloom, Bernard Khoo, Tricia M-M Tan
Published 2020-04-01

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

by Phil Pickford, Maria Lucey, Roxana-Maria Rujan, Emma Rose McGlone, Stavroula Bitsi, Fiona B. Ashford, Ivan R. Corrêa, David J. Hodson, Alejandra Tomas, Giuseppe Deganutti, Christopher A. Reynolds, Bryn M. Owen, Tricia M. Tan, James Minnion, Ben Jones, Stephen R. Bloom
Published 2021-09-01

Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells

by Zijian Fang, Shiqian Chen, Yusman Manchanda, Stavroula Bitsi, Philip Pickford, Alessia David, Maria M. Shchepinova, Ivan R. Corrêa Jr, David J. Hodson, Johannes Broichhagen, Edward W. Tate, Frank Reimann, Victoria Salem, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Published 2020-11-01

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

by Lucy Brooks, Alexander Viardot, Anastasia Tsakmaki, Emilie Stolarczyk, Jane K. Howard, Patrice D. Cani, Amandine Everard, Michelle L. Sleeth, Arianna Psichas, Jelena Anastasovskaj, Jimmy D. Bell, Kim Bell-Anderson, Charles R. Mackay, Mohammad A. Ghatei, Stephen R. Bloom, Gary Frost, Gavin A. Bewick
Published 2017-01-01

Sexual dimorphism of kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women

by Erik eHrabovszky, Csilla S. Molnar, Mate eSipos, Barbara eVida, Philippe eCiofi, Beata Agnes Borsay, Laszlo eSarkadi, Laszlo eHerczeg, Stephen R. Bloom, Mohammad A. Ghatei, Waljit S. Dhillo, Imre eKallo, Imre eKallo, Zsolt eLiposits, Zsolt eLiposits
Published 2011-12-01

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

by Teresa Buenaventura, Stavroula Bitsi, William E Laughlin, Thomas Burgoyne, Zekun Lyu, Affiong I Oqua, Hannah Norman, Emma R McGlone, Andrey S Klymchenko, Ivan R Corrêa, Abigail Walker, Asuka Inoue, Aylin Hanyaloglu, Jak Grimes, Zsombor Koszegi, Davide Calebiro, Guy A Rutter, Stephen R Bloom, Ben Jones, Alejandra Tomas
Published 2019-08-01

Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight

by Saira Hameed, Michael Patterson, Waljit S. Dhillo, Sofia A. Rahman, Yue Ma, Christopher Holton, Apostolos Gogakos, Giles S.H. Yeo, Brian Y.H. Lam, Joseph Polex-Wolf, Wiebke Fenske, Jimmy Bell, Jelena Anastasovska, Jacques Samarut, Stephen R. Bloom, J.H. Duncan Bassett, Graham R. Williams, James V. Gardiner
Published 2017-06-01

Targeting GLP-1 receptor trafficking to improve agonist efficacy

by Ben Jones, Teresa Buenaventura, Nisha Kanda, Pauline Chabosseau, Bryn M. Owen, Rebecca Scott, Robert Goldin, Napat Angkathunyakul, Ivan R. Corrêa Jr, Domenico Bosco, Paul R. Johnson, Lorenzo Piemonti, Piero Marchetti, A. M. James Shapiro, Blake J. Cochran, Aylin C. Hanyaloglu, Asuka Inoue, Tricia Tan, Guy A. Rutter, Alejandra Tomas, Stephen R. Bloom
Published 2018-04-01