CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis

by Qian Zhu, Nan Liu, Stuart H. Orkin, Guo-Cheng Yuan
Published 2019-09-01

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells

by Glenn A. MacLean, Jennifer McEldoon, Jialiang Huang, Jeremy Allred, Matthew C. Canver, Stuart. H. Orkin
Published 2018-05-01

Dissecting super-enhancer hierarchy based on chromatin interactions

by Jialiang Huang, Kailong Li, Wenqing Cai, Xin Liu, Yuannyu Zhang, Stuart H. Orkin, Jian Xu, Guo-Cheng Yuan
Published 2018-03-01

Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling

by Fatemeh Mirzamohammadi, Garyfallia Papaioannou, Jennifer B. Inloes, Erinn B. Rankin, Huafeng Xie, Ernestina Schipani, Stuart H. Orkin, Tatsuya Kobayashi
Published 2016-06-01

A single cis element maintains repression of the key developmental regulator Gata2.

by Jonathan W Snow, Jennifer J Trowbridge, Tohru Fujiwara, Nikla E Emambokus, Jeffrey A Grass, Stuart H Orkin, Emery H Bresnick
Published 2010-09-01

Correction: Corrigendum: LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice

by Jeesun Kim, Anup Kumar Singh, Yoko Takata, Kevin Lin, Jianjun Shen, Yue Lu, Marc A. Kerenyi, Stuart H. Orkin, Taiping Chen
Published 2016-04-01

Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis

by Guoji Guo, Luca Pinello, Xiaoping Han, Shujing Lai, Li Shen, Ta-Wei Lin, Keyong Zou, Guo-Cheng Yuan, Stuart H. Orkin
Published 2016-02-01

Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9

by Xin Liu, Yong Chen, Yuannyu Zhang, Yuxuan Liu, Nan Liu, Giovanni A. Botten, Hui Cao, Stuart H. Orkin, Michael Q. Zhang, Jian Xu
Published 2020-03-01

Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype

by Sidinh Luc, Jialiang Huang, Jennifer L. McEldoon, Ece Somuncular, Dan Li, Claire Rhodes, Shahan Mamoor, Serena Hou, Jian Xu, Stuart H. Orkin
Published 2016-09-01

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

by Marc A Kerenyi, Zhen Shao, Yu-Jung Hsu, Guoji Guo, Sidinh Luc, Kassandra O'Brien, Yuko Fujiwara, Cong Peng, Minh Nguyen, Stuart H Orkin
Published 2013-06-01

Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

by Lucy LeBlanc, Bum-Kyu Lee, Andy C Yu, Mijeong Kim, Aparna V Kambhampati, Shannon M Dupont, Davide Seruggia, Byoung U Ryu, Stuart H Orkin, Jonghwan Kim
Published 2018-12-01

Mapping the evolving landscape of super-enhancers during cell differentiation

by Yan Kai, Bin E. Li, Ming Zhu, Grace Y. Li, Fei Chen, Yingli Han, Hye Ji Cha, Stuart H. Orkin, Wenqing Cai, Jialiang Huang, Guo-Cheng Yuan
Published 2021-09-01

Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia

by Etienne Danis, Taylor Yamauchi, Kristen Echanique, Xi Zhang, Jessica N. Haladyna, Simone S. Riedel, Nan Zhu, Huafeng Xie, Stuart H. Orkin, Scott A. Armstrong, Kathrin M. Bernt, Tobias Neff
Published 2016-03-01

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5+ Intestinal Stem Cells

by Tae-Hee Kim, Assieh Saadatpour, Guoji Guo, Madhurima Saxena, Alessia Cavazza, Niyati Desai, Unmesh Jadhav, Lan Jiang, Miguel N. Rivera, Stuart H. Orkin, Guo-Cheng Yuan, Ramesh A. Shivdasani
Published 2016-08-01

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

by Thomas Barthlott, Adam E. Handel, Hong Ying Teh, Rushika C. Wirasinha, Katrin Hafen, Saulius Žuklys, Benoit Roch, Stuart H. Orkin, Jean-Pierre de Villartay, Stephen R. Daley, Georg A. Holländer
Published 2021-06-01

A unified model of human hemoglobin switching through single-cell genome editing

by Yong Shen, Jeffrey M. Verboon, Yuannyu Zhang, Nan Liu, Yoon Jung Kim, Samantha Marglous, Satish K. Nandakumar, Richard A. Voit, Claudia Fiorini, Ayesha Ejaz, Anindita Basak, Stuart H. Orkin, Jian Xu, Vijay G. Sankaran
Published 2021-08-01

Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer

by João D. Barros-Silva, Douglas E. Linn, Ivana Steiner, Guoji Guo, Adnan Ali, Hubert Pakula, Garry Ashton, Isabel Peset, Michael Brown, Noel W. Clarke, Roderick T. Bronson, Guo-Cheng Yuan, Stuart H. Orkin, Zhe Li, Esther Baena
Published 2018-12-01

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids.

by Ewa M Michalak, Michael J G Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Published 2018-08-01

EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent

by Shanshan Ai, Yong Peng, Chen Li, Fei Gu, Xianhong Yu, Yanzhu Yue, Qing Ma, Jinghai Chen, Zhiqiang Lin, Pingzhu Zhou, Huafeng Xie, Terence W Prendiville, Wen Zheng, Yuli Liu, Stuart H Orkin, Da-Zhi Wang, Jia Yu, William T Pu, Aibin He
Published 2017-04-01

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.

by David G Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S Trede, Noelle Paffett-Lugassy, Walter J Saganic, C Anthoney Lim, Candace Hersey, Yi Zhou, Bruce A Barut, Shuo Lin, Paul D Kingsley, James Palis, Stuart H Orkin, Leonard I Zon
Published 2004-08-01