Therapeutic efficacy of antibodies lacking Fcγ receptor binding against lethal dengue virus infection is due to neutralizing potency and blocking of enhancing antibodies [corrected...

by Katherine L Williams, Soila Sukupolvi-Petty, Martina Beltramello, Syd Johnson, Federica Sallusto, Antonio Lanzavecchia, Michael S Diamond, Eva Harris
Published 2013-02-01

Correction: Therapeutic Efficacy of Antibodies Lacking Fc. Receptor Binding against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodie...

by Katherine L. Williams, Soila Sukupolvi-Petty, Martina Beltramello, Syd Johnson, Federica Sallusto, Antonio Lanzavecchia, Michael S. Diamond, Eva Harris
Published 2013-03-01

Capturing a flavivirus pre-fusion intermediate.

by Bärbel Kaufmann, Paul R Chipman, Heather A Holdaway, Syd Johnson, Daved H Fremont, Richard J Kuhn, Michael S Diamond, Michael G Rossmann
Published 2009-11-01

Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope.

by S Kyle Austin, Kimberly A Dowd, Bimmi Shrestha, Christopher A Nelson, Melissa A Edeling, Syd Johnson, Theodore C Pierson, Michael S Diamond, Daved H Fremont
Published 2012-01-01

Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification.

by Scott J Balsitis, Katherine L Williams, Ruben Lachica, Diana Flores, Jennifer L Kyle, Erin Mehlhop, Syd Johnson, Michael S Diamond, P Robert Beatty, Eva Harris
Published 2010-02-01

The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1.

by Bimmi Shrestha, James D Brien, Soila Sukupolvi-Petty, S Kyle Austin, Melissa A Edeling, Taekyung Kim, Katie M O'Brien, Christopher A Nelson, Syd Johnson, Daved H Fremont, Michael S Diamond
Published 2010-04-01

Potent dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement.

by Melissa A Edeling, S Kyle Austin, Bimmi Shrestha, Kimberly A Dowd, Swati Mukherjee, Christopher A Nelson, Syd Johnson, Manu N Mabila, Elizabeth A Christian, Joseph Rucker, Theodore C Pierson, Michael S Diamond, Daved H Fremont
Published 2014-04-01

Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells.

by Derek D Sloan, Chia-Ying Kao Lam, Alivelu Irrinki, Liqin Liu, Angela Tsai, Craig S Pace, Jasmine Kaur, Jeffrey P Murry, Mini Balakrishnan, Paul A Moore, Syd Johnson, Jeffrey L Nordstrom, Tomas Cihlar, Scott Koenig
Published 2015-01-01

Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus.

by Pankaj Pal, Kimberly A Dowd, James D Brien, Melissa A Edeling, Sergey Gorlatov, Syd Johnson, Iris Lee, Wataru Akahata, Gary J Nabel, Mareike K S Richter, Jolanda M Smit, Daved H Fremont, Theodore C Pierson, Mark T Heise, Michael S Diamond
Published 2013-01-01

Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms

by Paola Circosta, Angela Rita Elia, Indira Landra, Rodolfo Machiorlatti, Maria Todaro, Sabrina Aliberti, Davide Brusa, Silvia Deaglio, Sabina Chiaretti, Riccardo Bruna, Daniela Gottardi, Massimo Massaia, Filomena Di Giacomo, Anna Rita Guarini, Robin Foà, Peter W. Kyriakides, Rohan Bareja, Olivier Elemento, Gurunadh R. Chichili, Emanuele Monteleone, Paul A. Moore, Syd Johnson, Ezio Bonvini, Alessandro Cignetti, Giorgio Inghirami
Published 2018-04-01

Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer

by Adam R. Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade, Jocelyn Sanford, Macy Jin, Cliona O’Sullivan, Emma Cummins, Matthew Lambert, Alfredo D. Sheehan, Weijun Ma, Scott Gatto, Kelvin Kerns, Khetemenee Lam, Aaron M. D’Antona, Lily Zhu, William A. Brady, Susan Benard, Amy King, Tao He, Lisa Racie, Maya Arai, Dianah Barrett, Wayne Stochaj, Edward R. LaVallie, James R. Apgar, Kristine Svenson, Lidia Mosyak, Yinhua Yang, Gurunadh R. Chichili, Liqin Liu, Hua Li, Steve Burke, Syd Johnson, Ralph Alderson, William J. J. Finlay, Laura Lin, Stéphane Olland, William Somers, Ezio Bonvini, Hans-Peter Gerber, Chad May, Paul A. Moore, Lioudmila Tchistiakova, Laird Bloom
Published 2016-03-01