Generating a Precision Endoxifen Prediction Algorithm to Advance Personalized Tamoxifen Treatment in Patients with Breast Cancer

by Thomas Helland, Sarah Alsomairy, Chenchia Lin, Håvard Søiland, Gunnar Mellgren, Daniel Louis Hertz
Published 2021-03-01

Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of mcf-7 breast cancer cells.

by Ingvild S Fenne, Thomas Helland, Marianne H Flågeng, Simon N Dankel, Gunnar Mellgren, Jørn V Sagen
Published 2013-01-01

Effect of Genetic Variability in 20 Pharmacogenes on Concentrations of Tamoxifen and Its Metabolites

by Yuanhuang Chen, Lauren A. Marcath, Finn Magnus Eliassen, Tone Hoel Lende, Havard Soiland, Gunnar Mellgren, Thomas Helland, Daniel Louis Hertz
Published 2021-06-01

The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells.

by Thomas Helland, Jennifer Gjerde, Simon Dankel, Ingvild S Fenne, Linn Skartveit, Andreas Drangevåg, Olivera Bozickovic, Marianne Hauglid Flågeng, Håvard Søiland, Gunnar Mellgren, Ernst A Lien
Published 2015-01-01

First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother: a case study

by Fedro Alessandro Peccatori, Giovanni Codacci-Pisanelli, Gunnar Mellgren, Barbara Buonomo, Eleonora Baldassarre, Ernst Asbjorn Lien, Ersilia Bifulco, Steinar Hustad, Emil Zachariassen, Harriet Johansson, Thomas Helland
Published 2020-10-01

Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

by Thomas Helland, Nina Henne, Ersilia Bifulco, Bjørn Naume, Elin Borgen, Vessela N. Kristensen, Jan T. Kvaløy, Timothy L. Lash, Grethe I. G. Alnæs, Ron H. van Schaik, Emiel A. M. Janssen, Steinar Hustad, Ernst A. Lien, Gunnar Mellgren, Håvard Søiland
Published 2017-11-01

Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial

by Andrea DeCensi, Harriet Johansson, Thomas Helland, Matteo Puntoni, Debora Macis, Valentina Aristarco, Silvia Caviglia, Tania Buttiron Webber, Irene Maria Briata, Mauro D’Amico, Davide Serrano, Aliana Guerrieri-Gonzaga, Ersilia Bifulco, Steinar Hustad, Håvard Søiland, Luca Boni, Bernardo Bonanni, Gunnar Mellgren
Published 2021-03-01

Low Z‐4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen

by Thomas Helland, Bjørn Naume, Steinar Hustad, Ersilia Bifulco, Jan Terje Kvaløy, Anna Barbro Sætersdal, Marit Synnestvedt, Tone Hoel Lende, Bjørnar Gilje, Ingvil Mjaaland, Kjetil Weyde, Egil Støre Blix, Gro Wiedswang, Elin Borgen, Daniel Louis Hertz, Emiel Adrianus Maria Janssen, Gunnar Mellgren, Håvard Søiland
Published 2021-04-01