Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia

by Bettina Wingelhofer, Tim C. P. Somervaille
Published 2019-09-01

The Diverse Consequences of <i>FOXC1</i> Deregulation in Cancer

by L. Niall Gilding, Tim C. P. Somervaille
Published 2019-02-01

AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells

by Stella Pearson, Rognvald Blance, Tim C.P. Somervaille, Anthony D. Whetton, Andrew Pierce
Published 2019-06-01

Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer

by Mark S. Williams, Naseer J. Basma, Fabio M. R. Amaral, Gillian Williams, John P. Weightman, Wolfgang Breitwieser, Louisa Nelson, Stephen S. Taylor, Daniel H. Wiseman, Tim C. P. Somervaille
Published 2020-11-01

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

by Tim D.D. Somerville, Fabrizio Simeoni, John A. Chadwick, Emma L. Williams, Gary J. Spencer, Katalin Boros, Christopher Wirth, Eleni Tholouli, Richard J. Byers, Tim C.P. Somervaille
Published 2018-01-01

Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

by Daniel J White, Richard D Unwin, Eric Bindels, Andrew Pierce, Hsiang-Ying Teng, Joanne Muter, Brigit Greystoke, Tim D Somerville, John Griffiths, Simon Lovell, Tim C P Somervaille, Ruud Delwel, Anthony D Whetton, Stefan Meyer
Published 2013-01-01

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

by Fabrizio Simeoni, Isabel Romero-Camarero, Francesco Camera, Fabio M.R. Amaral, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Michael Lie-A-Ling, Georges Lacaud, Daniel H. Wiseman, Jason S. Carroll, Tim C.P. Somervaille
Published 2021-09-01

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

by Alba Maiques-Diaz, Gary J. Spencer, James T. Lynch, Filippo Ciceri, Emma L. Williams, Fabio M.R. Amaral, Daniel H. Wiseman, William J. Harris, Yaoyong Li, Sudhakar Sahoo, James R. Hitchin, Daniel P. Mould, Emma E. Fairweather, Bohdan Waszkowycz, Allan M. Jordan, Duncan L. Smith, Tim C.P. Somervaille
Published 2018-03-01