Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

by Juraj Ahel, Anita Lehner, Antonia Vogel, Alexander Schleiffer, Anton Meinhart, David Haselbach, Tim Clausen
Published 2020-06-01

Structural Basis for Recognizing Phosphoarginine and Evolving Residue-Specific Protein Phosphatases in Gram-Positive Bacteria

by Jakob Fuhrmann, Beata Mierzwa, Débora B. Trentini, Silvia Spiess, Anita Lehner, Emmanuelle Charpentier, Tim Clausen
Published 2013-06-01

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

by Bence Hajdusits, Marcin J Suskiewicz, Nikolas Hundt, Anton Meinhart, Robert Kurzbauer, Julia Leodolter, Philipp Kukura, Tim Clausen
Published 2021-07-01

UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

by Doris Hellerschmied, Max Roessler, Anita Lehner, Linn Gazda, Karel Stejskal, Richard Imre, Karl Mechtler, Alexander Dammermann, Tim Clausen
Published 2018-02-01

Structural basis for the disaggregase activity and regulation of Hsp104

by Alexander Heuck, Sonja Schitter-Sollner, Marcin Józef Suskiewicz, Robert Kurzbauer, Juliane Kley, Alexander Schleiffer, Pascaline Rombaut, Franz Herzog, Tim Clausen
Published 2016-11-01

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

by Doris Hellerschmied, Anita Lehner, Nina Franicevic, Renato Arnese, Chloe Johnson, Antonia Vogel, Anton Meinhart, Robert Kurzbauer, Luiza Deszcz, Linn Gazda, Michael Geeves, Tim Clausen
Published 2019-10-01

The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains

by Alan Rodriguez Carvajal, Irina Grishkovskaya, Carlos Gomez Diaz, Antonia Vogel, Adar Sonn-Segev, Manish S Kushwah, Katrin Schodl, Luiza Deszcz, Zsuzsanna Orban-Nemeth, Shinji Sakamoto, Karl Mechtler, Philipp Kukura, Tim Clausen, David Haselbach, Fumiyo Ikeda
Published 2021-06-01

Mutations in the β-Tubulin Gene TUBB5 Cause Microcephaly with Structural Brain Abnormalities

by Martin Breuss, Julian Ik-Tsen Heng, Karine Poirier, Guoling Tian, Xavier Hubert Jaglin, Zhengdong Qu, Andreas Braun, Thomas Gstrein, Linh Ngo, Matilda Haas, Nadia Bahi-Buisson, Marie-Laure Moutard, Sandrine Passemard, Alain Verloes, Pierre Gressens, Yunli Xie, Kathryn J.H. Robson, Deepa Selvi Rani, Kumarasamy Thangaraj, Tim Clausen, Jamel Chelly, Nicholas Justin Cowan, David Anthony Keays
Published 2012-12-01

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

by Madlen Stephani, Lorenzo Picchianti, Alexander Gajic, Rebecca Beveridge, Emilio Skarwan, Victor Sanchez de Medina Hernandez, Azadeh Mohseni, Marion Clavel, Yonglun Zeng, Christin Naumann, Mateusz Matuszkiewicz, Eleonora Turco, Christian Loefke, Baiying Li, Gerhard Dürnberger, Michael Schutzbier, Hsiao Tieh Chen, Alibek Abdrakhmanov, Adriana Savova, Khong-Sam Chia, Armin Djamei, Irene Schaffner, Steffen Abel, Liwen Jiang, Karl Mechtler, Fumiyo Ikeda, Sascha Martens, Tim Clausen, Yasin Dagdas
Published 2020-08-01