A specific interface between integrin transmembrane helices and affinity for ligand.

by Bing-Hao Luo, Timothy A Springer, Junichi Takagi
Published 2004-06-01

Coordinated integrin activation by actin-dependent force during T-cell migration

by Pontus Nordenfelt, Hunter L. Elliott, Timothy A. Springer
Published 2016-10-01

Measuring Integrin Conformational Change on the Cell Surface with Super-Resolution Microscopy

by Travis I. Moore, Jesse Aaron, Teng-Leong Chew, Timothy A. Springer
Published 2018-02-01

General structural features that regulate integrin affinity revealed by atypical αVβ8

by Jianchuan Wang, Yang Su, Roxana E. Iacob, John R. Engen, Timothy A. Springer
Published 2019-12-01

Flow-induced elongation of von Willebrand factor precedes tension-dependent activation

by Hongxia Fu, Yan Jiang, Darren Yang, Friedrich Scheiflinger, Wesley P. Wong, Timothy A. Springer
Published 2017-08-01

Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

by Dennis Klug, Sarah Goellner, Jessica Kehrer, Julia Sattler, Léanne Strauss, Mirko Singer, Chafen Lu, Timothy A Springer, Friedrich Frischknecht
Published 2020-07-01

Design and assessment of TRAP-CSP fusion antigens as effective malaria vaccines.

by Chafen Lu, Gaojie Song, Kristin Beale, Jiabin Yan, Emma Garst, Juan Feng, Emily Lund, Flaminia Catteruccia, Timothy A Springer
Published 2020-01-01

Fusion surface structure, function, and dynamics of gamete fusogen HAP2

by Juan Feng, Xianchi Dong, Jennifer Pinello, Jun Zhang, Chafen Lu, Roxana E Iacob, John R Engen, William J Snell, Timothy A Springer
Published 2018-10-01

Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1.

by Sungkwon Kang, Chae Un Kim, Xiaoling Gu, Roisin M Owens, Sarah J van Rijn, Vanissra Boonyaleepun, Yuxin Mao, Timothy A Springer, Moonsoo M Jin
Published 2012-01-01

Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse [version 2; referees: 2 approved]

by Chiara Beilin, Kaushik Choudhuri, Gerben Bouma, Dessislava Malinova, Jaime Llodra, David L. Stokes, Motumu Shimaoka, Timothy A. Springer, Michael L. Dustin, Adrian J. Thrasher, Siobhan O. Burns
Published 2018-10-01

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics...

by Kristian E Swearingen, Scott E Lindner, Lirong Shi, Melanie J Shears, Anke Harupa, Christine S Hopp, Ashley M Vaughan, Timothy A Springer, Robert L Moritz, Stefan H I Kappe, Photini Sinnis
Published 2016-04-01

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

by Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen, David I. Stuart
Published 2017-05-01

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

by Pontus Nordenfelt, Travis I. Moore, Shalin B. Mehta, Joseph Mathew Kalappurakkal, Vinay Swaminathan, Nobuyasu Koga, Talley J. Lambert, David Baker, Jennifer C. Waters, Rudolf Oldenbourg, Tomomi Tani, Satyajit Mayor, Clare M. Waterman, Timothy A. Springer
Published 2017-12-01