Testing the limits of gradient sensing.

by Vinal Lakhani, Timothy C Elston
Published 2017-02-01

Particle-based simulations of polarity establishment reveal stochastic promotion of Turing pattern formation.

by Michael Pablo, Samuel A Ramirez, Timothy C Elston
Published 2018-03-01

Stochastic Methods for Inferring States of Cell Migration

by R. J. Allen, C. Welch, Neha Pankow, Klaus M. Hahn, Klaus M. Hahn, Timothy C. Elston, Timothy C. Elston
Published 2020-07-01

Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands.

by Vinal V Lakhani, Elizabeth Hinde, Enrico Gratton, Timothy C Elston
Published 2015-01-01

Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks.

by Marcelo Behar, Nan Hao, Henrik G Dohlman, Timothy C Elston
Published 2008-10-01

In silico generation of alternative hypotheses using causal mapping (CMAP).

by Gabriel E Weinreb, Maryna T Kapustina, Ken Jacobson, Timothy C Elston
Published 2009-01-01

A novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement.

by Samuel A Ramirez, Michael Pablo, Sean Burk, Daniel J Lew, Timothy C Elston
Published 2021-07-01

A whole-body model for glycogen regulation reveals a critical role for substrate cycling in maintaining blood glucose homeostasis.

by Ke Xu, Kevin T Morgan, Abby Todd Gehris, Timothy C Elston, Shawn M Gomez
Published 2011-12-01

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing.

by Jamie L Nosbisch, Anisur Rahman, Krithika Mohan, Timothy C Elston, James E Bear, Jason M Haugh
Published 2020-04-01

Dose-Duration Reciprocity for G protein activation: Modulation of kinase to substrate ratio alters cell signaling.

by Kang-Ling Liao, Charles E Melvin, Rosangela Sozzani, Roger D Jones, Timothy C Elston, Alan M Jones
Published 2017-01-01

Principles that govern competition or co-existence in Rho-GTPase driven polarization.

by Jian-Geng Chiou, Samuel A Ramirez, Timothy C Elston, Thomas P Witelski, David G Schaeffer, Daniel J Lew
Published 2018-04-01

Deep learning enables structured illumination microscopy with low light levels and enhanced speed

by Luhong Jin, Bei Liu, Fenqiang Zhao, Stephen Hahn, Bowei Dong, Ruiyan Song, Timothy C. Elston, Yingke Xu, Klaus M. Hahn
Published 2020-04-01

Ratiometric GPCR signaling enables directional sensing in yeast.

by Nicholas T Henderson, Michael Pablo, Debraj Ghose, Manuella R Clark-Cotton, Trevin R Zyla, James Nolen, Timothy C Elston, Daniel J Lew
Published 2019-10-01

Role of competition between polarity sites in establishing a unique front

by Chi-Fang Wu, Jian-Geng Chiou, Maria Minakova, Benjamin Woods, Denis Tsygankov, Trevin R Zyla, Natasha S Savage, Timothy C Elston, Daniel J Lew
Published 2015-11-01

Modeling the Excess Cell Surface Stored in a Complex Morphology of Bleb-Like Protrusions.

by Maryna Kapustina, Denis Tsygankov, Jia Zhao, Timothy Wessler, Xiaofeng Yang, Alex Chen, Nathan Roach, Timothy C Elston, Qi Wang, Ken Jacobson, M Gregory Forest
Published 2016-03-01

An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration

by Virginia Tajadura-Ortega, Ritu Garg, Richard Allen, Claudia Owczarek, Michael D. Bright, Samuel Kean, Aisyah Mohd-Noor, Anita Grigoriadis, Timothy C. Elston, Klaus M. Hahn, Anne J. Ridley
Published 2018-03-01