Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa.

by Timothy C Nichols, Howard Levy, Elizabeth P Merricks, Robin A Raymer, Martin L Lee
Published 2020-01-01

Global measurement of coagulation in plasma from normal and haemophilia dogs using a novel modified thrombin generation test - Demonstrated in vitro and ex vivo.

by Daniel Elenius Madsen, Timothy C Nichols, Elizabeth P Merricks, Emily K Waters, Bo Wiinberg
Published 2017-01-01

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

by David M. Markusic, Timothy C. Nichols, Elizabeth P. Merricks, Brett Palaschak, Irene Zolotukhin, Damien Marsic, Sergei Zolotukhin, Arun Srivastava, Roland W. Herzog
Published 2017-05-01

Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs.

by Bryan T Davis, Xiao-Jun Wang, Judy A Rohret, Jason T Struzynski, Elizabeth P Merricks, Dwight A Bellinger, Frank A Rohret, Timothy C Nichols, Christopher S Rogers
Published 2014-01-01

Oxidized LDL and Fructosamine Associated with Severity of Coronary Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High NaCl Diet.

by Timothy C Nichols, Elizabeth P Merricks, Dwight A Bellinger, Robin A Raymer, Jing Yu, Diana Lam, Gary G Koch, Walker H Busby, David R Clemmons
Published 2015-01-01

Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

by Xiaolei Pei, Wenwei Shao, Allene Xing, Charles Askew, Xiaojing Chen, Caibin Cui, Yasmina L. Abajas, David A. Gerber, Elizabeth P. Merricks, Timothy C. Nichols, Wuping Li, R. Jude Samulski, Chengwen Li
Published 2020-09-01

An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs

by Junjiang Sun, Wenwei Shao, Xiaojing Chen, Elizabeth P. Merricks, Lauren Wimsey, Yasmina L. Abajas, Glenn P. Niemeyer, Clinton D. Lothrop, Paul E. Monahan, R. Jude Samulski, Timothy C. Nichols, Chengwen Li
Published 2018-09-01