Human Pluripotent Stem Cells to Model Islet Defects in Diabetes

by Diego Balboa, Diepiriye G. Iworima, Diepiriye G. Iworima, Timothy J. Kieffer, Timothy J. Kieffer, Timothy J. Kieffer
Published 2021-03-01

Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia

by Anna M. D'souza, Timothy J. Kieffer
Published 2017-06-01

Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells.

by Blair K Gage, Travis D Webber, Timothy J Kieffer
Published 2013-01-01

Clinical Application of Glucagon-Like Peptide 1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus

by Young Min Cho, Rhonda D. Wideman, Timothy J. Kieffer
Published 2013-12-01

Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lepob/ob mice

by Anna M. D'souza, James D. Johnson, Susanne M. Clee, Timothy J. Kieffer
Published 2016-11-01

The glucoregulatory actions of leptin

by Anna M. D'souza, Ursula H. Neumann, Maria M. Glavas, Timothy J. Kieffer
Published 2017-09-01

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

by Jennifer E. Bruin, Ali Asadi, Jessica K. Fox, Suheda Erener, Alireza Rezania, Timothy J. Kieffer
Published 2015-12-01

Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice

by Satoko Shimazu-Kuwahara, Norio Harada, Shunsuke Yamane, Erina Joo, Akiko Sankoda, Timothy J. Kieffer, Nobuya Inagaki
Published 2017-03-01

FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1

by Michelle M. Kwon, Shannon M. O’Dwyer, Robert K. Baker, Scott D. Covey, Timothy J. Kieffer
Published 2015-11-01

Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination.

by Eva Tudurí, Jennifer E Bruin, Heather C Denroche, Jessica K Fox, James D Johnson, Timothy J Kieffer
Published 2013-01-01

Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

by Ursula H. Neumann, Jessica S.S. Ho, Majid Mojibian, Scott D. Covey, Maureen J. Charron, Timothy J. Kieffer
Published 2016-08-01

Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets

by Queenie Hui, Ali Asadi, Yoo Jin Park, Timothy J. Kieffer, Ziliang Ao, Garth L. Warnock, Lucy Marzban
Published 2017-08-01

Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes

by Ursula H. Neumann, Jessica S.S. Ho, Sam Chen, Yuen Yi C. Tam, Pieter R. Cullis, Timothy J. Kieffer
Published 2017-10-01

The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

by Heather C. Denroche, Michelle M. Kwon, Maria M. Glavas, Eva Tudurí, Marion Philippe, Whitney L. Quong, Timothy J. Kieffer
Published 2016-08-01

Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats

by Maria M. Glavas, Queenie Hui, Ian Miao, Fan Yang, Suheda Erener, Kacey J. Prentice, Michael B. Wheeler, Timothy J. Kieffer
Published 2021-07-01

Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice

by Satoko Shimazu‐Kuwahara, Yoshinori Kanemaru, Norio Harada, Eri Ikeguchi, Yohei Ueda, Shunsuke Yamane, Yuki Murata, Akihiro Yasoda, Timothy J Kieffer, Nobuya Inagaki
Published 2019-07-01

Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects

by Tsuyoshi Yanagimachi, Yukihiro Fujita, Yasutaka Takeda, Jun Honjo, Hidemitsu Sakagami, Hiroya Kitsunai, Yumi Takiyama, Atsuko Abiko, Yuichi Makino, Timothy J. Kieffer, Masakazu Haneda
Published 2017-02-01

The Role of ARX in Human Pancreatic Endocrine Specification.

by Blair K Gage, Ali Asadi, Robert K Baker, Travis D Webber, Rennian Wang, Masayuki Itoh, Masaharu Hayashi, Rie Miyata, Takumi Akashi, Timothy J Kieffer
Published 2015-01-01

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

by Jennifer E. Bruin, Suheda Erener, Javier Vela, Xiaoke Hu, James D. Johnson, Harley T. Kurata, Francis C. Lynn, James M. Piret, Ali Asadi, Alireza Rezania, Timothy J. Kieffer
Published 2014-01-01

AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells

by Eva Tudurí, Maria M. Glavas, Ali Asadi, Robert K. Baker, Cara E. Ellis, Galina Soukhatcheva, Marjolaine Philit, Frank K. Huynh, James D. Johnson, C. Bruce Verchere, Timothy J. Kieffer
Published 2019-07-01