Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus

by Tomohiro Koga, Tomohiro Koga, Kunihiro Ichinose, Atsushi Kawakami, George C. Tsokos
Published 2021-02-01

TNF-α-induced miR-155 regulates IL-6 signaling in rheumatoid synovial fibroblasts

by Kiyoshi Migita, Nozomi Iwanaga, Yasumori Izumi, Chieko Kawahara, Kenji Kumagai, Tadashi Nakamura, Tomohiro Koga, Atsushi Kawakami
Published 2017-08-01

Comparison of the efficacy and safety of tocilizumab for colchicine-resistant or colchicine-intolerant familial Mediterranean fever: study protocol for an investigator-initiated, m...

by Tomohiro Koga, Shuntaro Sato, Junya Miyamoto, Naoko Hagimori, Yurika Kawazoe, Kumiko Arinaga, Chizu Fukushima, Hiroshi Yamamoto, Atsushi Kawakami
Published 2018-12-01

Elevated serum levels of checkpoint molecules in patients with adult Still’s disease

by Yuya Fujita, Tomoyuki Asano, Haruki Matsumoto, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Makiko Yashiro Furuya, Eiji Suzuki, Hiroshi Watanabe, Tomohiro Koga, Atsushi Kawakami, Kiyoshi Migita
Published 2020-07-01

M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis

by Shoichi Fukui, Shoichi Fukui, Naoki Iwamoto, Ayuko Takatani, Takashi Igawa, Toshimasa Shimizu, Masataka Umeda, Masataka Umeda, Ayako Nishino, Ayako Nishino, Yoshiro Horai, Yoshiro Horai, Yasuko Hirai, Tomohiro Koga, Tomohiro Koga, Shin-ya Kawashiri, Shin-ya Kawashiri, Mami Tamai, Kunihiro Ichinose, Hideki Nakamura, Tomoki Origuchi, Tomoki Origuchi, Ritsuko Masuyama, Kosuke Kosai, Katsunori Yanagihara, Atsushi Kawakami
Published 2018-01-01

Frequency of Hospitalized Infections Is Reduced in Rheumatoid Arthritis Patients Who Received Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drugs after 2010

by Kunihiro Ichinose, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Ayako Nishino, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Mami Tamai, Hideki Nakamura, Shuntaro Sato, Tomoki Origuchi, Atsushi Kawakami
Published 2018-01-01

Juvenile onset autoinflammatory disease due to a novel mutation in TNFAIP3 (A20)

by Shuzo Sato, Yuya Fujita, Tomonari Shigemura, Hisanori Matoba, Kazunaga Agematsu, Yuya Sumichika, Makiko Yashiro, Atsushi Ono, Yukihiko Kawasaki, Hiroko Kobayashi, Hiroshi Watanabe, Tomohiro Koga, Atsushi Kawakami, Kiyoshi Migita
Published 2018-12-01

Poly (I:C) and hyaluronic acid directly interact with NLRP3, resulting in the assembly of NLRP3 and ASC in a cell-free system

by Naoe Kaneko, Yuki Ito, Tomoyuki Iwasaki, Hiroyuki Takeda, Tatsuya Sawasaki, Kiyoshi Migita, Kazunaga Agematsu, Tomohiro Koga, Atsushi Kawakami, Akihiro Yachie, Koh-ichiro Yoshiura, Shinnosuke Morikawa, Mie Kurata, Junya Masumoto
Published 2017-08-01

Tofacitinib inhibits granulocyte–macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils

by Makiko Yashiro Furuya, Tomoyuki Asano, Yuya Sumichika, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Hiromasa Ohira, Hideharu Sekine, Atsushi Kawakami, Kiyoshi Migita
Published 2018-08-01

Hydroxychloroquine inhibits IL-1β production from amyloid-stimulated human neutrophils

by Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro Furuya, Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Takeshi Urano, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Atsushi Kawakami, Kiyoshi Migita
Published 2019-11-01

Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease

by Shin-ya Kawashiri, Tomoki Origuchi, Masataka Umeda, Ayako Nishino, Toshimasa Shimizu, Shoichi Fukui, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Takahiro Maeda, Mitsuhiro Kawano, Motohisa Yamamoto, Yasumori Izumi, Atsushi Kawakami
Published 2018-12-01

ICER is requisite for Th17 differentiation

by Nobuya Yoshida, Denis Comte, Masayuki Mizui, Kotaro Otomo, Florencia Rosetti, Tanya N. Mayadas, José C. Crispín, Sean J. Bradley, Tomohiro Koga, Michihito Kono, Maria P. Karampetsou, Vasileios C. Kyttaris, Klaus Tenbrock, George C. Tsokos
Published 2016-09-01

Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever.

by Michio Yasunami, Hitomi Nakamura, Kazunaga Agematsu, Akinori Nakamura, Masahide Yazaki, Dai Kishida, Akihiro Yachie, Tomoko Toma, Junya Masumoto, Hiroaki Ida, Tomohiro Koga, Atsushi Kawakami, Katsumi Eguchi, Hiroshi Furukawa, Tadashi Nakamura, Minoru Nakamura, Kiyoshi Migita
Published 2015-01-01

Infectious Pneumonia and Lower Airway Microorganisms in Patients with Rheumatoid Arthritis

by Shuhei Ideguchi, Kazuko Yamamoto, Masahiro Tahara, Tomohiro Koga, Shotaro Ide, Tatsuro Hirayama, Takahiro Takazono, Yoshifumi Imamura, Taiga Miyazaki, Noriho Sakamoto, Shimpei Morimoto, Koichi Izumikawa, Katsunori Yanagihara, Kazuto Ashizawa, Takatoshi Aoki, Atsushi Kawakami, Kazuhiro Yatera, Hiroshi Mukae
Published 2021-08-01

Osteogenic differentiation of fibroblast-like synovial cells in rheumatoid arthritis is induced by microRNA-218 through a ROBO/Slit pathway

by Naoki Iwamoto, Shoichi Fukui, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Ayako Nishino, Takashi Igawa, Tomohiro Koga, Shin-ya Kawashiri, Kunihiro Ichinose, Mami Tmai, Hideki Nakamura, Tomoki Origuchi, Ko Chiba, Makoto Osaki, Astrid Jüngel, Steffen Gay, Atsushi Kawakami
Published 2018-08-01

Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort

by Kunihiro Ichinose, Mineaki Kitamura, Shuntaro Sato, Keita Fujikawa, Yoshiro Horai, Naoki Matsuoka, Masahiko Tsuboi, Fumiaki Nonaka, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Takashi Igawa, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Tomoya Nishino, Atsushi Kawakami
Published 2020-07-01

A case of neutrophilic dermatosis with MEFV gene variant and abnormal activation of peripheral blood monocytes: a case report

by Mizuna Otsuka, Tomohiro Koga, Remi Sumiyoshi, Yuta Koike, Kaori Furukawa, Momoko Okamoto, Yushiro Endo, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Takashi Igawa, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Niino Daisuke, Atsushi Kawakami
Published 2019-01-01

The contribution of SAA1 polymorphisms to Familial Mediterranean fever susceptibility in the Japanese population.

by Kiyoshi Migita, Kazunaga Agematsu, Junya Masumoto, Hiroaki Ida, Seiyo Honda, Yuka Jiuchi, Yasumori Izumi, Yumi Maeda, Ritei Uehara, Yoshikazu Nakamura, Tomohiro Koga, Atsushi Kawakami, Munetoshi Nakashima, Yuichiro Fujieda, Fumiaki Nonaka, Katsumi Eguchi, Hiroshi Furukawa, Tadashi Nakamura, Minoru Nakamura, Michio Yasunami
Published 2013-01-01

Interleukin-18 and fibroblast growth factor 2 in combination is a useful diagnostic biomarker to distinguish adult-onset Still’s disease from sepsis

by Tomohiro Koga, Remi Sumiyoshi, Kaori Furukawa, Shuntaro Sato, Kiyoshi Migita, Toshimasa Shimizu, Masataka Umeda, Yushiro Endo, Shoichi Fukui, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Fumiaki Nonaka, Akihiro Yachie, Hideaki Kondo, Takahiro Maeda, Atsushi Kawakami
Published 2020-05-01

Efficacy and safety at 24 weeks of daily clinical use of tofacitinib in patients with rheumatoid arthritis.

by Naoki Iwamoto, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Shoichi Fukui, Masataka Umeda, Ayako Nishino, Yoshiro Horai, Tomohiro Koga, Shin-Ya Kawashiri, Toshiyuki Aramaki, Kunihiro Ichinose, Yasuko Hirai, Mami Tamai, Hideki Nakamura, Kaoru Terada, Tomoki Origuchi, Katsumi Eguchi, Yukitaka Ueki, Atsushi Kawakami
Published 2017-01-01