Structural Insights into the Regulation Mechanism of Small GTPases by GEFs

by Sachiko Toma-Fukai, Toshiyuki Shimizu
Published 2019-09-01

Crystal structure of NOD2 and its implications in human disease

by Sakiko Maekawa, Umeharu Ohto, Takuma Shibata, Kensuke Miyake, Toshiyuki Shimizu
Published 2016-06-01

Can Material and Energy Be Saved by Differentiating Water Quality Targets in the Water Purification Process?

by Sébastien M. R. Dente, Toshiyuki Shimizu, Tao Wang, Seiji Hashimoto
Published 2020-10-01

Suppression of Matrix Metalloproteinase Production in Nasal Fibroblasts by Tranilast, an Antiallergic Agent, In Vitro

by Toshiyuki Shimizu, Kenichi Kanai, Kazuhito Asano, Tadashi Hisamitsu, Harumi Suzaki
Published 2005-01-01

Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga

by Yuqun Xu, Takuya Miyakawa, Shohei Nosaki, Akira Nakamura, Ying Lyu, Hidemitsu Nakamura, Umeharu Ohto, Hanako Ishida, Toshiyuki Shimizu, Tadao Asami, Masaru Tanokura
Published 2018-09-01

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands

by Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, Masato Taoka, Yoshio Yamauchi, Ryota Sato, Nikunj M. Shukla, Sunil A. David, Toshiaki Isobe, Kensuke Miyake, Toshiyuki Shimizu
Published 2018-12-01

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

by Lakshmi Ganapathi, Simon Van Haren, David J Dowling, Ilana Bergelson, Nikunj M Shukla, Subbalakshmi S Malladi, Rajalakshmi Balakrishna, Hiromi Tanji, Umeharu Ohto, Toshiyuki Shimizu, Sunil A David, Ofer Levy
Published 2015-01-01

Structural analysis reveals TLR7 dynamics underlying antagonism

by Shingo Tojo, Zhikuan Zhang, Hiroyuki Matsui, Masahiro Tahara, Mitsunori Ikeguchi, Mami Kochi, Mami Kamada, Hideki Shigematsu, Akihisa Tsutsumi, Naruhiko Adachi, Takuma Shibata, Masaki Yamamoto, Masahide Kikkawa, Toshiya Senda, Yoshiaki Isobe, Umeharu Ohto, Toshiyuki Shimizu
Published 2020-10-01

Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFβ signaling.

by Junko Matsuoka, Masakazu Yashiro, Yosuke Doi, Yuhiko Fuyuhiro, Yukihiro Kato, Osamu Shinto, Satoru Noda, Shinichiro Kashiwagi, Naoki Aomatsu, Toshiki Hirakawa, Tsuyoshi Hasegawa, Kiyoshi Shimizu, Toshiyuki Shimizu, Atsushi Miwa, Nobuya Yamada, Tetsuji Sawada, Kosei Hirakawa
Published 2013-01-01

Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

by Yi Yang, Adam Csakai, Shuangshuang Jiang, Christina Smith, Hiromi Tanji, Jian Huang, Torey Jones, Kentaro Sakaniwa, Lindsey Broadwell, Chengrui Shi, Subada Soti, Umeharu Ohto, Yaohui Fang, Shu Shen, Fei Deng, Toshiyuki Shimizu, Hang Yin
Published 2021-07-01

Effects of Different Types of Cognitive Training on Cognitive Function, Brain Structure, and Driving Safety in Senior Daily Drivers: A Pilot Study

by Takayuki Nozawa, Yasuyuki Taki, Akitake Kanno, Yoritaka Akimoto, Mizuki Ihara, Ryoichi Yokoyama, Yuka Kotozaki, Rui Nouchi, Atsushi Sekiguchi, Hikaru Takeuchi, Carlos Makoto Miyauchi, Takeshi Ogawa, Takakuni Goto, Takashi Sunda, Toshiyuki Shimizu, Eiji Tozuka, Satoru Hirose, Tatsuyoshi Nanbu, Ryuta Kawashima
Published 2015-01-01