SUMOylation is required for optimal TRAF3 signaling capacity.

by Sophia Miliara, Kalliopi K Gkouskou, Tyson V Sharp, Aristides G Eliopoulos
Published 2013-01-01

SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians.

by Cristina González-Estévez, Daniel A Felix, Matthew D Smith, Jordi Paps, Simon J Morley, Victoria James, Tyson V Sharp, A Aziz Aboobaker
Published 2012-01-01

Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity

by Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers
Published 2021-01-01

Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters

by Duncan C. Miller, Stephen C. Harmer, Ariel Poliandri, Muriel Nobles, Elizabeth C. Edwards, James S. Ware, Tyson V. Sharp, Tristan R. McKay, Leo Dunkel, Pier D. Lambiase, Andrew Tinker
Published 2017-12-01

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins

by Katherine S. Bridge, Kunal M. Shah, Yigen Li, Daniel E. Foxler, Sybil C.K. Wong, Duncan C. Miller, Kathryn M. Davidson, John G. Foster, Ruth Rose, Michael R. Hodgkinson, Paulo S. Ribeiro, A. Aziz Aboobaker, Kenta Yashiro, Xiaozhong Wang, Paul R. Graves, Michael J. Plevin, Dimitris Lagos, Tyson V. Sharp
Published 2017-07-01

A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia

by Daniel E Foxler, Katherine S Bridge, John G Foster, Paul Grevitt, Sean Curry, Kunal M Shah, Kathryn M Davidson, Ai Nagano, Emanuela Gadaleta, Hefin I Rhys, Paul T Kennedy, Miguel A Hermida, Ting‐Yu Chang, Peter E Shaw, Louise E Reynolds, Tristan R McKay, Hsei‐Wei Wang, Paulo S Ribeiro, Michael J Plevin, Dimitris Lagos, Nicholas R Lemoine, Prabhakar Rajan, Trevor A Graham, Claude Chelala, Kairbaan M Hodivala‐Dilke, Ian Spendlove, Tyson V Sharp
Published 2018-08-01