564 Potency-reduced and extended half-life IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity with potentially improved therapeutic index compared to native IL12 agen...

by Ke Liu, Christine Bonzon, Seung Chu, Rumana Rashid, Umesh Muchhal, John Desjarlais, Matthew Bernett, Nicole Rodriguez, Nargess Hassanzadeh-Kiabi, Connie Ardila
Published 2020-11-01

697 Tumor-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors

by Gregory Moore, Michael Hedvat, Christine Bonzon, Rumana Rashid, Umesh Muchhal, John Desjarlais, Irene Leung, Veronica Zeng, Juan Diaz, Kendra Avery, Norm Bartlow, Charles Bakhit, Matthew Dragovich, Liz Bogart
Published 2020-11-01

718 AMG 509, a STEAP1 x CD3 bispecific XmAb® 2+1 immune therapy, exhibits avidity-driven binding and preferential killing of high STEAP1-expressing prostate and Ewing sarcoma cance...

by Cong Li, Gregory Moore, Umesh Muchhal, John Desjarlais, Matthew Bernett, Madeline Fort, Lingming Liang, Tao Osgood, Rodolfo Yabut, Sarav Kaliyaperumal, John Harrold, Jude Canon, Anna Rogojina, Raushan Kurmasheva, Peter Houghton, Olivier Nolan-Stevaux
Published 2020-11-01