Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology?

by Alon Greenbaum, Min J. Jang, Collin Challis, Viviana Gradinaru
Published 2017-09-01

Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization.

by Claire N Bedbrook, Kevin K Yang, Austin J Rice, Viviana Gradinaru, Frances H Arnold
Published 2017-10-01

Exposing the Three-Dimensional Biogeography and Metabolic States of Pathogens in Cystic Fibrosis Sputum via Hydrogel Embedding, Clearing, and rRNA Labeling

by William H. DePas, Ruth Starwalt-Lee, Lindsey Van Sambeek, Sripriya Ravindra Kumar, Viviana Gradinaru, Dianne K. Newman
Published 2016-09-01

Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model.

by Inna Sukhotinsky, Alexander M Chan, Omar J Ahmed, Vikram R Rao, Viviana Gradinaru, Charu Ramakrishnan, Karl Deisseroth, Ania K Majewska, Sydney S Cash
Published 2013-01-01

Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses

by Anat Kahan, Alon Greenbaum, Min J. Jang, J. Elliott Robinson, Jounhong Ryan Cho, Xinhong Chen, Pegah Kassraian, Daniel A. Wagenaar, Viviana Gradinaru
Published 2021-09-01

Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1

by J Elliott Robinson, Gerard M Coughlin, Acacia M Hori, Jounhong Ryan Cho, Elisha D Mackey, Zeynep Turan, Tommaso Patriarchi, Lin Tian, Viviana Gradinaru
Published 2019-09-01

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice

by Jianxiong Zeng, Yaoming Wang, Zhifei Luo, Lin-Chun Chang, Ji Seung Yoo, Huan Yan, Younho Choi, Xiaochun Xie, Benjamin E. Deverman, Viviana Gradinaru, Stephanie L. Gupton, Berislav V. Zlokovic, Zhen Zhao, Jae U. Jung
Published 2019-04-01

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

by Timothy R Sampson, Collin Challis, Neha Jain, Anastasiya Moiseyenko, Mark S Ladinsky, Gauri G Shastri, Taren Thron, Brittany D Needham, Istvan Horvath, Justine W Debelius, Stefan Janssen, Rob Knight, Pernilla Wittung-Stafshede, Viviana Gradinaru, Matthew Chapman, Sarkis K Mazmanian
Published 2020-02-01

Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

by Pradeep S. Rajendran, Rosemary C. Challis, Charless C. Fowlkes, Peter Hanna, John D. Tompkins, Maria C. Jordan, Sarah Hiyari, Beth A. Gabris-Weber, Alon Greenbaum, Ken Y. Chan, Benjamin E. Deverman, Heike Münzberg, Jeffrey L. Ardell, Guy Salama, Viviana Gradinaru, Kalyanam Shivkumar
Published 2019-04-01

Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

by Jai Woong Seo, Elizabeth S. Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C. Flytzanis, Michael Chavez, Kratika Singhal, Ryan Leib, Michelle L. James, David J. Segal, R. Holland Cheng, Eduardo A. Silva, Viviana Gradinaru, Katherine W. Ferrara
Published 2020-04-01

Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics

by Adolfo Ramirez-Zamora, James Giordano, Edward S. Boyden, Edward S. Boyden, Edward S. Boyden, Viviana Gradinaru, Aysegul Gunduz, Philip A. Starr, Sameer A. Sheth, Cameron C. McIntyre, Michael D. Fox, Jerrold Vitek, Vinata Vedam-Mai, Umer Akbar, Leonardo Almeida, Helen M. Bronte-Stewart, Helen S. Mayberg, Nader Pouratian, Aryn H. Gittis, Annabelle C. Singer, Meaghan C. Creed, Gabriel Lazaro-Munoz, Mark Richardson, Marvin A. Rossi, Leopoldo Cendejas-Zaragoza, Pierre-Francois D’Haese, Winston Chiong, Ro’ee Gilron, Howard Chizeck, Andrew Ko, Kenneth B. Baker, Joost Wagenaar, Noam Harel, Wissam Deeb, Kelly D. Foote, Michael S. Okun
Published 2019-09-01

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

by John K. Mich, Lucas T. Graybuck, Erik E. Hess, Joseph T. Mahoney, Yoshiko Kojima, Yi Ding, Saroja Somasundaram, Jeremy A. Miller, Brian E. Kalmbach, Cristina Radaelli, Bryan B. Gore, Natalie Weed, Victoria Omstead, Yemeserach Bishaw, Nadiya V. Shapovalova, Refugio A. Martinez, Olivia Fong, Shenqin Yao, Marty Mortrud, Peter Chong, Luke Loftus, Darren Bertagnolli, Jeff Goldy, Tamara Casper, Nick Dee, Ximena Opitz-Araya, Ali Cetin, Kimberly A. Smith, Ryder P. Gwinn, Charles Cobbs, Andrew L. Ko, Jeffrey G. Ojemann, C. Dirk Keene, Daniel L. Silbergeld, Susan M. Sunkin, Viviana Gradinaru, Gregory D. Horwitz, Hongkui Zeng, Bosiljka Tasic, Ed S. Lein, Jonathan T. Ting, Boaz P. Levi
Published 2021-03-01