SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline.

by Takamune T Saito, Firaz Mohideen, Katherine Meyer, J Wade Harper, Monica P Colaiácovo
Published 2012-08-01

An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.

by Nadia Litterman, Yoshiho Ikeuchi, Gilbert Gallardo, Brenda C O'Connell, Mathew E Sowa, Steven P Gygi, J Wade Harper, Azad Bonni
Published 2011-05-01

QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology

by Virginia Guarani, Elizabeth M McNeill, Joao A Paulo, Edward L Huttlin, Florian Fröhlich, Steven P Gygi, David Van Vactor, J Wade Harper
Published 2015-05-01

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors

by Lior Izhar, Britt Adamson, Alberto Ciccia, Jedd Lewis, Laura Pontano-Vaites, Yumei Leng, Anthony C. Liang, Thomas F. Westbrook, J. Wade Harper, Stephen J. Elledge
Published 2015-06-01

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

by Joseph D Mancias, Laura Pontano Vaites, Sahar Nissim, Douglas E Biancur, Andrew J Kim, Xiaoxu Wang, Yu Liu, Wolfram Goessling, Alec C Kimmelman, J Wade Harper
Published 2015-10-01

Endosomal Rab cycles regulate Parkin-mediated mitophagy

by Koji Yamano, Chunxin Wang, Shireen A Sarraf, Christian Münch, Reika Kikuchi, Nobuo N Noda, Yohei Hizukuri, Masato T Kanemaki, Wade Harper, Keiji Tanaka, Noriyuki Matsuda, Richard J Youle
Published 2018-01-01

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

by Tim Ahfeldt, Alban Ordureau, Christina Bell, Lily Sarrafha, Chicheng Sun, Silvia Piccinotti, Tobias Grass, Gustavo M. Parfitt, Joao A. Paulo, Fumiki Yanagawa, Takayuki Uozumi, Yasujiro Kiyota, J. Wade Harper, Lee L. Rubin
Published 2020-01-01

The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis

by Saravanapriah Nadarajan, Firaz Mohideen, Yonatan B Tzur, Nuria Ferrandiz, Oliver Crawley, Alex Montoya, Peter Faull, Ambrosius P Snijders, Pedro R Cutillas, Ashwini Jambhekar, Michael D Blower, Enrique Martinez-Perez, J Wade Harper, Monica P Colaiacovo
Published 2016-02-01

EDF1 coordinates cellular responses to ribosome collisions

by Niladri K Sinha, Alban Ordureau, Katharina Best, James A Saba, Boris Zinshteyn, Elayanambi Sundaramoorthy, Amit Fulzele, Danielle M Garshott, Timo Denk, Matthias Thoms, Joao A Paulo, J Wade Harper, Eric J Bennett, Roland Beckmann, Rachel Green
Published 2020-08-01

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

by Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias, Alec C. Kimmelman
Published 2017-07-01

QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease

by Virginia Guarani, Claude Jardel, Dominique Chrétien, Anne Lombès, Paule Bénit, Clémence Labasse, Emmanuelle Lacène, Agnès Bourillon, Apolline Imbard, Jean-François Benoist, Imen Dorboz, Mylène Gilleron, Eric S Goetzman, Pauline Gaignard, Abdelhamid Slama, Monique Elmaleh-Bergès, Norma B Romero, Pierre Rustin, Hélène Ogier de Baulny, Joao A Paulo, J Wade Harper, Manuel Schiff
Published 2016-09-01