3C Viral Proteases Ampelopsis Ampelopsis grossedentata Ampelopsis grossedentata extract Antiviral Agents Article Binding Sites Covalent inhibitors Cysteine Flavonoids Flavonols IC50 Mass Spectrometry Metal resistance Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation Multidrug resistance Plant Extracts Protease Inhibitors Protein Binding Protein Conformation SARS-CoV-2 SARS-CoV-2 3CLpro Salmonella Rissen Severe acute respiratory syndrome coronavirus 2 Tn7 antivirus agent binding site chemical composition