Adolescent Adult Anticoagulation Reversal Article Bayes Theorem Bayes theorem Blood Platelets Broadly Neutralizing Antibodies Dose-Response Relationship, Drug Double-Blind Method Female Healthy Volunteers Humans Immunoglobulin Fragments Male Middle Aged Models, Biological PB-2452 Platelet Aggregation Inhibitors Ticagrelor Young Adult administration and dosage adolescent adult aged alanine aminotransferase alkaline phosphatase antiplatelet activity antithrombocytic agent aspartate aminotransferase