MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs.

by Dong Lu, Matthew P A Davis, Cei Abreu-Goodger, Wei Wang, Lia S Campos, Julia Siede, Elena Vigorito, William C Skarnes, Ian Dunham, Anton J Enright, Pentao Liu
Published 2012-01-01

Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines.

by Matthew P A Davis, Cei Abreu-Goodger, Stijn van Dongen, Dong Lu, Peri H Tate, Nenad Bartonicek, Claudia Kutter, Pentao Liu, William C Skarnes, Anton J Enright, Ian Dunham
Published 2012-01-01

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

by Paula A. Coelho, Leah Bury, Marta N. Shahbazi, Kifayathullah Liakath-Ali, Peri H. Tate, Sam Wormald, Christopher J. Hindley, Meritxell Huch, Joy Archer, William C. Skarnes, Magdalena Zernicka-Goetz, David M. Glover
Published 2015-01-01

Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries

by Emmanouil Metzakopian, Alex Strong, Vivek Iyer, Alex Hodgkins, Konstantinos Tzelepis, Liliana Antunes, Mathias J Friedrich, Qiaohua Kang, Teresa Davidson, Jacob Lamberth, Christina Hoffmann, Gregory D. Davis, George S. Vassiliou, William C. Skarnes, Allan Bradley
Published 2017-05-01

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

by Amy T. Y. Yeung, Christine Hale, Amy H. Lee, Erin E. Gill, Wendy Bushell, David Parry-Smith, David Goulding, Derek Pickard, Theodoros Roumeliotis, Jyoti Choudhary, Nick Thomson, William C. Skarnes, Gordon Dougan, Robert E. W. Hancock
Published 2017-04-01

Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.

by Alex S Nord, Karen Vranizan, Whittemore Tingley, Alexander C Zambon, Kristina Hanspers, Loren G Fong, Yan Hu, Peter Bacchetti, Thomas E Ferrin, Patricia C Babbitt, Scott W Doniger, William C Skarnes, Stephen G Young, Bruce R Conklin
Published 2007-07-01

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

by Michael R. Bowl, Michelle M. Simon, Neil J. Ingham, Simon Greenaway, Luis Santos, Heather Cater, Sarah Taylor, Jeremy Mason, Natalja Kurbatova, Selina Pearson, Lynette R. Bower, Dave A. Clary, Hamid Meziane, Patrick Reilly, Osamu Minowa, Lois Kelsey, The International Mouse Phenotyping Consortium, Glauco P. Tocchini-Valentini, Xiang Gao, Allan Bradley, William C. Skarnes, Mark Moore, Arthur L. Beaudet, Monica J. Justice, John Seavitt, Mary E. Dickinson, Wolfgang Wurst, Martin Hrabe de Angelis, Yann Herault, Shigeharu Wakana, Lauryl M. J. Nutter, Ann M. Flenniken, Colin McKerlie, Stephen A. Murray, Karen L. Svenson, Robert E. Braun, David B. West, K. C. Kent Lloyd, David J. Adams, Jacqui White, Natasha Karp, Paul Flicek, Damian Smedley, Terrence F. Meehan, Helen E. Parkinson, Lydia M. Teboul, Sara Wells, Karen P. Steel, Ann-Marie Mallon, Steve D. M. Brown
Published 2017-10-01