Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory s...

by Xinyuan Li, Pu Fang, Yu Sun, Ying Shao, William Y. Yang, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Published 2020-01-01

GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg

by Keman Xu, Keman Xu, William Y. Yang, William Y. Yang, Gayani Kanchana Nanayakkara, Gayani Kanchana Nanayakkara, Ying Shao, Ying Shao, Fan Yang, Wenhui Hu, Wenhui Hu, Eric T. Choi, Eric T. Choi, Hong Wang, Hong Wang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang
Published 2018-01-01

Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling

by Wen Shen, Chao Gao, Ramon Cueto, Lu Liu, Hangfei Fu, Ying Shao, William Y. Yang, Pu Fang, Eric T. Choi, Qinghua Wu, Xiaofeng Yang, Hong Wang
Published 2020-01-01

Approaching Inflammation Paradoxes—Proinflammatory Cytokine Blockages Induce Inflammatory Regulators

by Ming Liu, Ming Liu, Jason Saredy, Ruijing Zhang, Ruijing Zhang, Ying Shao, Yu Sun, William Y. Yang, William Y. Yang, Jirong Wang, Jirong Wang, Lu Liu, Charles Drummer, Candice Johnson, Fatma Saaoud, Yifan Lu, Keman Xu, Li Li, Xin Wang, Xiaohua Jiang, Xiaohua Jiang, Hong Wang, Hong Wang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang
Published 2020-10-01

ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes

by Yu Sun, Yifan Lu, Jason Saredy, Xianwei Wang, Charles Drummer IV, Ying Shao, Fatma Saaoud, Keman Xu, Ming Liu, William Y. Yang, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Published 2020-10-01

Identification of homocysteine-suppressive mitochondrial ETC complex genes and tissue expression profile – Novel hypothesis establishment

by Ramon Cueto, Lixiao Zhang, Hui Min Shan, Xiao Huang, Xinyuan Li, Ya-feng Li, Jahaira Lopez, William Y. Yang, Muriel Lavallee, Catherine Yu, Yong Ji, Xiaofeng Yang, Hong Wang
Published 2018-07-01

Thrombus leukocytes exhibit more endothelial cell-specific angiogenic markers than peripheral blood leukocytes do in acute coronary syndrome patients, suggesting a possibility of t...

by Hangfei Fu, Nish Vadalia, Eric R. Xue, Candice Johnson, Luqiao Wang, William Y. Yang, Claudette Sanchez, Jun Nelson, Qian Chen, Eric T. Choi, Jian-Xing Ma, Jun Yu, Hong Wang, Xiaofeng Yang
Published 2017-03-01

Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of C...

by Jiwei Wang, Jiwei Wang, Jiwei Wang, Jiwei Wang, Bin Lai, Bin Lai, Bin Lai, Bin Lai, Gayani Nanayakkara, Gayani Nanayakkara, Gayani Nanayakkara, Qian Yang, Qian Yang, Qian Yang, Yu Sun, Yu Sun, Yu Sun, Yifan Lu, Yifan Lu, Yifan Lu, Ying Shao, Ying Shao, Ying Shao, Daohai Yu, William Y. Yang, William Y. Yang, William Y. Yang, Ramon Cueto, Ramon Cueto, Ramon Cueto, Hangfei Fu, Hangfei Fu, Hangfei Fu, Huihong Zeng, Huihong Zeng, Huihong Zeng, Wen Shen, Wen Shen, Wen Shen, Susu Wu, Susu Wu, Susu Wu, Chunquan Zhang, Yanna Liu, Eric T. Choi, Eric T. Choi, Eric T. Choi, Eric T. Choi, Hong Wang, Hong Wang, Hong Wang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang
Published 2019-07-01

Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells – Novel qualification...

by Yifan Lu, Yu Sun, Charles Drummer, IV, Gayani K. Nanayakkara, Ying Shao, Fatma Saaoud, Candice Johnson, Ruijing Zhang, Daohai Yu, Xinyuan Li, William Y. Yang, Jun Yu, Xiaohua Jiang, Eric T. Choi, Hong Wang, Xiaofeng Yang
Published 2019-06-01

Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

by Luqiao Wang, Hangfei Fu, Gayani Nanayakkara, Yafeng Li, Ying Shao, Candice Johnson, Jiali Cheng, William Y. Yang, Fan Yang, Muriel Lavallee, Yanjie Xu, Xiaoshu Cheng, Hang Xi, Jonathan Yi, Jun Yu, Eric T. Choi, Hong Wang, Xiaofeng Yang
Published 2016-11-01

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks

by Huihong Zeng, Gayani K. Nanayakkara, Gayani K. Nanayakkara, Ying Shao, Ying Shao, Hangfei Fu, Hangfei Fu, Yu Sun, Yu Sun, Ramon Cueto, Ramon Cueto, William Y. Yang, William Y. Yang, Qian Yang, Qian Yang, Qian Yang, Haitao Sheng, Haitao Sheng, Haitao Sheng, Na Wu, Na Wu, Na Wu, Luqiao Wang, Luqiao Wang, Luqiao Wang, Wuping Yang, Hongping Chen, Lijian Shao, Jianxin Sun, Xuebin Qin, Joon Y. Park, Konstantinos Drosatos, Konstantinos Drosatos, Eric T. Choi, Eric T. Choi, Qingxian Zhu, Hong Wang, Hong Wang, Xiaofeng Yang, Xiaofeng Yang
Published 2018-05-01

Increasing Upstream Chromatin Long–Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells

by Angus Li, Angus Li, Yu Sun, Charles Drummer, Yifan Lu, Daohai Yu, Yan Zhou, Xinyuan Li, Simone J. Pearson, Candice Johnson, Catherine Yu, William Y. Yang, Kevin Mastascusa, Xiaohua Jiang, Jianxin Sun, Thomas Rogers, Wenhui Hu, Hong Wang, Xiaofeng Yang, Xiaofeng Yang
Published 2019-04-01

Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exos...

by Qian Yang, Qian Yang, Gayani K. Nanayakkara, Charles Drummer, Yu Sun, Candice Johnson, Ramon Cueto, Hangfei Fu, Ying Shao, Luqiao Wang, Luqiao Wang, William Y. Yang, Peng Tang, Li-Wen Liu, Shuping Ge, Shuping Ge, Xiao-Dong Zhou, Mohsin Khan, Hong Wang, Xiaofeng Yang
Published 2017-10-01

A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

by Luqiao Wang, Gayani Nanayakkara, Qian Yang, Hongmei Tan, Charles Drummer, Yu Sun, Ying Shao, Hangfei Fu, Ramon Cueto, Huimin Shan, Teodoro Bottiglieri, Ya-feng Li, Candice Johnson, William Y. Yang, Fan Yang, Yanjie Xu, Hang Xi, Weiqing Liu, Jun Yu, Eric T. Choi, Xiaoshu Cheng, Hong Wang, Xiaofeng Yang
Published 2017-10-01

End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progressi...

by Ruijing Zhang, Jason Saredy, Ying Shao, Tian Yao, Lu Liu, Fatma Saaoud, William Y. Yang, Yu Sun, Candice Johnson, Charles Drummer, IV, Hangfei Fu, Yifan Lu, Keman Xu, Ming Liu, Jirong Wang, Elizabeth Cutler, Daohai Yu, Xiaohua Jiang, Yafeng Li, Rongshan Li, Lihua Wang, Eric T. Choi, Hong Wang, Xiaofeng Yang
Published 2020-07-01

Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators

by Ming Liu, Ming Liu, Na Wu, Keman Xu, Fatma Saaoud, Eleni Vasilopoulos, Ying Shao, Ruijing Zhang, Ruijing Zhang, Jirong Wang, Jirong Wang, Haitao Shen, William Y. Yang, Yifan Lu, Yu Sun, Charles Drummer, Lu Liu, Li Li, Wenhui Hu, Jun Yu, Domenico Praticò, Jianxin Sun, Xiaohua Jiang, Xiaohua Jiang, Hong Wang, Xiaofeng Yang, Xiaofeng Yang
Published 2021-07-01

Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors

by Bin Lai, Bin Lai, Jiwei Wang, Jiwei Wang, Alexander Fagenson, Alexander Fagenson, Yu Sun, Jason Saredy, Yifan Lu, Gayani Nanayakkara, William Y. Yang, Daohai Yu, Ying Shao, Charles Drummer, Candice Johnson, Fatma Saaoud, Ruijing Zhang, Qian Yang, Keman Xu, Kevin Mastascusa, Ramon Cueto, Hangfei Fu, Susu Wu, Lizhe Sun, Peiqian Zhu, Xuebin Qin, Xuebin Qin, Jun Yu, Daping Fan, Ying H. Shen, Ying H. Shen, Jianxin Sun, Thomas Rogers, Eric T. Choi, Eric T. Choi, Eric T. Choi, Hong Wang, Xiaofeng Yang, Xiaofeng Yang
Published 2019-11-01