A mechanistic compartmental model for total antibody uptake in tumors

by Thurber, Greg M., Wittrup, Karl Dane
Published 2022

Activation of tolerogenic dendritic cells in the tumor draining lymph CD8+ T cells engineered to express CD40 ligand

by Higham, Eileen M., Wittrup, Karl Dane, Chen, Jianzhu
Published 2012

Integrated Mimicry of B Cell Antibody Mutagenesis Using Yeast Homologous Recombination

by Swers, Jeffrey Seth, Yeung, Yik Andy, Wittrup, Karl Dane
Published 2020

A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

by Liu, David V., Yang, Nicole Jie Yeon, Wittrup, Karl Dane
Published 2014

Cutting Edge: Delay and Reversal of T Cell Tolerance by Intratumoral Injection of Antigen-Loaded Dendritic Cells in an Autochthonous Tumor Model

by Higham, Eileen M., Wittrup, Karl Dane, Chen, Jianzhu, Shen, Chase
Published 2012

CD8[superscript +] T-cell Responses Rapidly Select for Antigen-Negative Tumor Cells in the Prostate

by Bak, S. Peter G., Barnkob, Mike Stein, Wittrup, Karl Dane, Chen, Jianzhu
Published 2014

Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design

by Kulkarni, Chethana, Betts, Alison M., Wittrup, Karl Dane, Maass, Katie F
Published 2016

Equilibrium and dynamic design principles for binding molecules engineered for reagentless biosensors

by De Picciotto, Seymour, Imperiali, Barbara, Griffith, Linda G, Wittrup, Karl Dane
Published 2016

Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles

by Su, Xingfang, Yang, Nicole Jie Yeon, Wittrup, Karl Dane, Irvine, Darrell J
Published 2013

Targeted Cytolysins Synergistically Potentiate Cytoplasmic Delivery of Gelonin Immunotoxin

by Wittrup, K. D., Pirie, Christopher M., Liu, David V., Wittrup, Karl Dane
Published 2016

Practical Theoretic Guidance for the Design of Tumor-Targeting Agents

by Thurber, Greg M., Schmidt, Michael M., Rhoden, John J., Wittrup, Karl Dane
Published 2016

Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity

by Kwong, Brandon, Gai, S. Annie, Elkhader, Jamal, Wittrup, Karl Dane, Irvine, Darrell J
Published 2014

Epidermal growth factor receptor downregulation by small heterodimeric binding proteins

by Hackel, Benjamin J., Neil, Jason Robert, White, Forest M., Wittrup, Karl Dane
Published 2013

Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution

by Tzeng, Alice, Navaratna, Tejas, Kwan, Byron Hua, Opel, Cary Francis, Wittrup, Karl Dane
Published 2015

Engineered gp120 immunogens that elicit VRC01-like antibodies by vaccination

by Mata-Fink, Jordi, Hanson, M., Kriegsman, Barry A., Irvine, Darrell J., Wittrup, Karl Dane
Published 2013

Effect of Small-Molecule-Binding Affinity on Tumor Uptake In Vivo: A Systematic Study Using a Pretargeted Bispecific Antibody

by Rhoden, John J., Ruiz-Yi, Benjamin, Wittrup, Karl Dane, Frangioni, John V., Orcutt, Kelly Davis
Published 2014

Triepitopic Antibody Fusions Inhibit Cetuximab-Resistant BRAF and KRAS Mutant Tumors via EGFR Signal Repression

by Manzari, Mandana T., Rosalia, Elizabeth K., Chen, Tiffany Fen-yi, Wittrup, Karl Dane, Spangler, Jamie Berta
Published 2014

Differential Requirement for CD70 and CD80/CD86 in Dendritic Cellmediated Activation of Tumor Tolerized CD8 T Cells

by Barnkob, Mike Stein, Bai, Ailin, Higham, Eileen M., Wittrup, Karl Dane, Chen, Jianzhu, Bak, Peter
Published 2012

A Flow Cytometric Clonogenic Assay Reveals the Single-Cell Potency of Doxorubicin

by Kulkarni, Chethana, Betts, Alison M., Maass, Katie F., Quadir, Mohiuddin Abdul, Hammond, Paula T., Wittrup, Karl Dane
Published 2017