The Vav GEF Family: An Evolutionary and Functional Perspective

by Sonia Rodríguez-Fdez, Xosé R. Bustelo
Published 2019-05-01

The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.

by Sergio Ruiz, Eugenio Santos, Xosé R Bustelo
Published 2009-12-01

In Silico Analysis of the Age-Dependent Evolution of the Transcriptome of Mouse Skin Stem Cells

by L. Francisco Lorenzo-Martín, Xosé R. Bustelo
Published 2020-01-01

Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head an...

by Luis Francisco Lorenzo-Martín, Mauricio Menacho-Márquez, Xosé R. Bustelo
Published 2020-09-01

Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation.

by Antonio Castro-Castro, Olivia Muriel, Miguel A Del Pozo, Xosé R Bustelo
Published 2016-01-01

Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes

by Sonia Rodríguez-Fdez, Lucía Fernández-Nevado, L. Francisco Lorenzo-Martín, Xosé R. Bustelo
Published 2020-03-01

Identification of distinct maturation steps involved in human 40S ribosomal subunit biosynthesis

by Blanca Nieto, Sonia G. Gaspar, Giulia Moriggi, Dimitri G. Pestov, Xosé R. Bustelo, Mercedes Dosil
Published 2020-01-01

Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis

by Javier Conde, Isabel Fernández-Pisonero, Myriam Cuadrado, Antonio Abad, Javier Robles-Valero, Xosé R. Bustelo
Published 2021-06-01

The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly.

by Marta Pires de Miranda, Marta Alenquer, Sofia Marques, Lénia Rodrigues, Filipa Lopes, Xosé R Bustelo, J Pedro Simas
Published 2008-02-01

Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity

by Nazareno González, Georgina A. Cardama, Georgina A. Cardama, Patricio Chinestrad, Javier Robles-Valero, Javier Robles-Valero, Javier Robles-Valero, Sonia Rodríguez-Fdez, Sonia Rodríguez-Fdez, Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, L. Francisco Lorenzo-Martín, L. Francisco Lorenzo-Martín, Xosé R. Bustelo, Xosé R. Bustelo, Xosé R. Bustelo, Pablo Lorenzano Menna, Pablo Lorenzano Menna, Daniel E. Gomez, Daniel E. Gomez
Published 2020-04-01

New Functions of Vav Family Proteins in Cardiovascular Biology, Skeletal Muscle, and the Nervous System

by Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Salvatore Fabbiano, Mauricio Menacho-Márquez, Vincent Sauzeau, Mercedes Dosil, Xosé R. Bustelo
Published 2021-09-01

HERC Ubiquitin Ligases in Cancer

by Joan Sala-Gaston, Arturo Martinez-Martinez, Leonardo Pedrazza, L. Francisco Lorenzo-Martín, Rubén Caloto, Xosé R. Bustelo, Francesc Ventura, Jose Luis Rosa
Published 2020-06-01

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.

by Mauricio Menacho-Márquez, Ramón García-Escudero, Virginia Ojeda, Antonio Abad, Pilar Delgado, Clotilde Costa, Sergio Ruiz, Balbino Alarcón, Jesús M Paramio, Xosé R Bustelo
Published 2013-07-01

Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.

by Victoria Campuzano, Maria Segura-Puimedon, Verena Terrado, Carolina Sánchez-Rodríguez, Mathilde Coustets, Mauricio Menacho-Márquez, Julián Nevado, Xosé R Bustelo, Uta Francke, Luis A Pérez-Jurado
Published 2012-02-01

Loss of Aryl Hydrocarbon Receptor Favors <i>K-Ras</i>^G12D-Driven Non-Small Cell Lung Cancer

by Ana Nacarino-Palma, Claudia M. Rejano-Gordillo, Francisco J. González-Rico, Ana Ordiales-Talavero, Ángel C. Román, Myriam Cuadrado, Xosé R. Bustelo, Jaime M. Merino, Pedro M. Fernández-Salguero
Published 2021-08-01

Lung regeneration after toxic injury is improved in absence of dioxin receptor

by Antonio Morales-Hernández, Ana Nacarino-Palma, Nuria Moreno-Marín, Eva Barrasa, Beroé Paniagua-Quiñones, Inmaculada Catalina-Fernández, Alberto Alvarez-Barrientos, Xosé R. Bustelo, Jaime M. Merino, Pedro M. Fernández-Salguero
Published 2017-12-01

Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis

by Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Isabel Fernández-Pisonero, Begoña Porteiro, Christelle Veyrat-Durebex, Daniel Beiroa, Omar Al-Massadi, Antonio Abad, Carlos Diéguez, Roberto Coppari, Rubén Nogueiras, Xosé R. Bustelo
Published 2020-11-01

Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis

by Fernando C. Baltanás, Cynthia Mucientes-Valdivieso, L. Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Rósula García-Navas, Carmen Segrelles, Nuria Calzada, Rocío Fuentes-Mateos, Jesús M. Paramio, Xosé R. Bustelo, Eugenio Santos
Published 2021-04-01

RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation

by Berta Casar, Andrew P. Badrock, Iñaki Jiménez, Imanol Arozarena, Paula Colón-Bolea, L. Francisco Lorenzo-Martín, Irene Barinaga-Rementería, Jorge Barriuso, Vincenzo Cappitelli, Daniel J. Donoghue, Xosé R. Bustelo, Adam Hurlstone, Piero Crespo
Published 2018-09-01

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

by Parastoo Shahrouzi, Ianire Astobiza, Ana R. Cortazar, Verónica Torrano, Alice Macchia, Juana M. Flores, Chiara Niespolo, Isabel Mendizabal, Ruben Caloto, Amaia Ercilla, Laura Camacho, Leire Arreal, Maider Bizkarguenaga, Maria L. Martinez-Chantar, Xose R. Bustelo, Edurne Berra, Endre Kiss-Toth, Guillermo Velasco, Amaia Zabala-Letona, Arkaitz Carracedo
Published 2020-09-01