Adult Antidepressive Agents Article Cerebral Cortex Connectome Default Mode Network Depressive Disorder, Major Duloxetine Hydrochloride Escitalopram Female Follow-Up Studies Hamilton Depression Rating Scale Humans Magnetic Resonance Imaging Male Nerve Net Treatment Outcome Young Adult adult adverse event antidepressant activity antidepressant agent antidepressants big data brain cortex brain network clinical assessment clinical trial connectome controlled study