Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs

by Koji Nishikawa, Yosuke Osawa, Kiminori Kimura
Published 2018-10-01

Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells.

by Yosuke Osawa, Masato Hoshi, Ichiro Yasuda, Toshiji Saibara, Hisataka Moriwaki, Osamu Kozawa
Published 2013-01-01

Immune Determinants in the Acquisition and Maintenance of Antibody to Hepatitis B Surface Antigen in Adults After First‐Time Hepatitis B Vaccination

by Hiroyoshi Doi, Sachiyo Yoshio, Keiichiro Yoneyama, Hironari Kawai, Yuzuru Sakamoto, Tomonari Shimagaki, Yoshihiko Aoki, Yosuke Osawa, Hitoshi Yoshida, Tatsuya Kanto
Published 2019-06-01

Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice

by Yosuke Osawa, Keisuke Oboki, Jun Imamura, Ekumi Kojika, Yukiko Hayashi, Tsunekazu Hishima, Toshiji Saibara, Futoshi Shibasaki, Michinori Kohara, Kiminori Kimura
Published 2015-11-01

Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model

by Yuko Tokunaga, Yosuke Osawa, Takahiro Ohtsuki, Yukiko Hayashi, Kenzaburo Yamaji, Daisuke Yamane, Mitsuko Hara, Keisuke Munekata, Kyoko Tsukiyama-Kohara, Tsunekazu Hishima, Soichi Kojima, Kiminori Kimura, Michinori Kohara
Published 2017-03-01

Cluster of Differentiation 44 Promotes Liver Fibrosis and Serves as a Biomarker in Congestive Hepatopathy

by Yosuke Osawa, Hironari Kawai, Tomoyuki Tsunoda, Haruki Komatsu, Miku Okawara, Yuriko Tsutsui, Yuichi Yoshida, Shiori Yoshikawa, Taizo Mori, Taiji Yamazoe, Sachiyo Yoshio, Takashi Oide, Ayano Inui, Tatsuya Kanto
Published 2021-08-01

Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients

by Yosuke Osawa, Sachiyo Yoshio, Yoshihiko Aoki, Masaaki Korenaga, Masatoshi Imamura, Takashi Oide, Miku Okawara, Hironari Kawai, Yuriko Tsutsui, Yuichi Yoshida, Shiori Yoshikawa, Taizo Mori, Taiji Yamazoe, Tatsuya Kanto
Published 2021-02-01

Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Singl...

by Kiminori Kimura, Akemi Ikoma, Maki Shibakawa, Shinji Shimoda, Kenichi Harada, Masanao Saio, Jun Imamura, Yosuke Osawa, Masamichi Kimura, Koji Nishikawa, Takuji Okusaka, Satoshi Morita, Kazuaki Inoue, Tatsuya Kanto, Koji Todaka, Yoichi Nakanishi, Michinori Kohara, Masashi Mizokami
Published 2017-09-01

Increased Frequency of Dysfunctional Siglec-7−CD57+PD-1+ Natural Killer Cells in Patients With Non-alcoholic Fatty Liver Disease

by Yuzuru Sakamoto, Yuzuru Sakamoto, Sachiyo Yoshio, Hiroyoshi Doi, Taizo Mori, Michitaka Matsuda, Hironari Kawai, Tomonari Shimagaki, Shiori Yoshikawa, Yoshihiko Aoki, Yosuke Osawa, Yuji Yoshida, Taeang Arai, Norio Itokawa, Masanori Atsukawa, Takanori Ito, Takashi Honda, Yoshihiro Mise, Yoshihiro Ono, Yu Takahashi, Akio Saiura, Akinobu Taketomi, Tatsuya Kanto
Published 2021-02-01