MicroRNAs and Their Therapeutic Potential for Human Diseases: MicroRNAs, miR-143 and -145, Function as Anti-oncomirs and the Application of Chemically Modified miR-143 as an Anti-c...

by Yukio Kitade, Yukihiro Akao
Published 2010-01-01

Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen

by Yoshinori Nozawa, Yoshihito Nakagawa, Yukihiro Akao
Published 2008-03-01

Synthetic MIR143-3p Suppresses Cell Growth in Rhabdomyosarcoma Cells by Interrupting RAS Pathways Including PAX3–FOXO1

by Nobuhiko Sugito, Kazuki Heishima, Yuko Ito, Yukihiro Akao
Published 2020-11-01

Extracellular Vesicles Containing MicroRNA-92a-3p Facilitate Partial Endothelial-Mesenchymal Transition and Angiogenesis in Endothelial Cells

by Nami O. Yamada, Kazuki Heishima, Yukihiro Akao, Takao Senda
Published 2019-09-01

Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract

by Masakazu Hashimoto, Tsuyoshi Nakai, Teruaki Masutani, Keiko Unno, Yukihiro Akao
Published 2020-06-01

Extracellular Disposal of Tumor-Suppressor miRs-145 and -34a via Microvesicles and 5-FU Resistance of Human Colon Cancer Cells

by Yukihiro Akao, Fiona Khoo, Minami Kumazaki, Haruka Shinohara, Kohei Miki, Nami Yamada
Published 2014-01-01

Tumor Tissue MIR92a and Plasma MIRs21 and 29a as Predictive Biomarkers Associated with Clinicopathological Features and Surgical Resection in a Prospective Study on Colorectal Canc...

by Masahiro Fukada, Nobuhisa Matsuhashi, Takao Takahashi, Nobuhiko Sugito, Kazuki Heishima, Yukihiro Akao, Kazuhiro Yoshida
Published 2020-08-01

Lig-8, a Bioactive Lignophenol Derivative From Bamboo Lignin, Protects Against Neuronal Damage In Vitro and In Vivo

by Yasushi Ito, Masamitsu Shimazawa, Yukihiro Akao, Yoshimi Nakajima, Norio Seki, Yoshinori Nozawa, Hideaki Hara
Published 2006-01-01

A Novel Role of Dickkopf-Related Protein 3 in Macropinocytosis in Human Bladder Cancer T24 Cells

by Nonoka Tsujimura, Nami O. Yamada, Yuki Kuranaga, Minami Kumazaki, Haruka Shinohara, Kohei Taniguchi, Yukihiro Akao
Published 2016-11-01

MicroRNA-214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1-p53 Axis.

by Kazuki Heishima, Takashi Mori, Hiroki Sakai, Nobuhiko Sugito, Mami Murakami, Nami Yamada, Yukihiro Akao, Kohji Maruo
Published 2015-01-01

A Potent Apoptosis-Inducing Activity of a Sesquiterpene Lactone, Arucanolide, in HL60 Cells: a Crucial Role of Apoptosis-Inducing Factor

by Yoshihito Nakagawa, Munekazu Iinuma, Nobuyasu Matsuura, Kong Yi, Makoto Naoi, Toshihiro Nakayama, Yoshinori Nozawa, Yukihiro Akao
Published 2005-01-01

Ewing sarcoma cells secrete EWS/Fli-1 fusion mRNA via microvesicles.

by Masanori Tsugita, Nami Yamada, Shunsuke Noguchi, Kazunari Yamada, Hiroshi Moritake, Katsuji Shimizu, Yukihiro Akao, Takatoshi Ohno
Published 2013-01-01

Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression

by Kohei Taniguchi, Nobuhiko Sugito, Haruka Shinohara, Yuki Kuranaga, Yosuke Inomata, Kazumasa Komura, Kazuhisa Uchiyama, Yukihiro Akao
Published 2018-04-01

SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells

by Yuki Kuranaga, Nobuhiko Sugito, Haruka Shinohara, Takuya Tsujino, Kohei Taniguchi, Kazumasa Komura, Yuko Ito, Tomoyoshi Soga, Yukihiro Akao
Published 2018-10-01

DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells

by Toshihiro Tajirika, Yoshihisa Tokumaru, Kohei Taniguchi, Nobuhiko Sugito, Nobuhisa Matsuhashi, Manabu Futamura, Kazuyoshi Yanagihara, Yukihiro Akao, Kazuhiro Yoshida
Published 2018-07-01

Synthetic miR-143 Inhibits Growth of HER2-Positive Gastric Cancer Cells by Suppressing KRAS Networks Including DDX6 RNA Helicase

by Yoshihisa Tokumaru, Toshihiro Tajirika, Nobuhiko Sugito, Yuki Kuranaga, Haruka Shinohara, Takuya Tsujino, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida
Published 2019-04-01

Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer

by Yoshihisa Tokumaru, Masanori Oshi, Michelle R. Huyser, Li Yan, Masahiro Fukada, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takabe
Published 2021-07-01

High Expression of miR-34a Associated with Less Aggressive Cancer Biology but Not with Survival in Breast Cancer

by Yoshihisa Tokumaru, Eriko Katsuta, Masanori Oshi, Judith C. Sporn, Li Yan, Lan Le, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takabe
Published 2020-04-01

High Expression of microRNA-143 is Associated with Favorable Tumor Immune Microenvironment and Better Survival in Estrogen Receptor Positive Breast Cancer

by Yoshihisa Tokumaru, Mariko Asaoka, Masanori Oshi, Eriko Katsuta, Li Yan, Sumana Narayanan, Nobuhiko Sugito, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takabe
Published 2020-05-01

Anti-cancer Effects of a Chemically Modified miR-143 on Bladder Cancer by Either Systemic or Intravesical Treatment

by Yuki Yoshikawa, Kohei Taniguchi, Takuya Tsujino, Kazuki Heishima, Teruo Inamoto, Tomoaki Takai, Koichiro Minami, Haruhito Azuma, Kanjiro Miyata, Kotaro Hayashi, Kazunori Kataoka, Yukihiro Akao
Published 2019-06-01