Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells

by Yusaku Nakabeppu
Published 2014-07-01

Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease

by Kyota Fujita, Yusaku Nakabeppu, Mami Noda
Published 2011-01-01

Oxidative Stress and Microglial Response in Retinitis Pigmentosa

by Yusuke Murakami, Yusaku Nakabeppu, Koh-Hei Sonoda
Published 2020-09-01

Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes

by Kyota Fujita, Megumi Yamafuji, Yusaku Nakabeppu, Mami Noda
Published 2012-01-01

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

by Shinji Asada, Eiko Ohta, Yoriko Akimoto, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu
Published 2017-07-01

8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction.

by Harini Sampath, Vladimir Vartanian, M Rick Rollins, Kunihiko Sakumi, Yusaku Nakabeppu, R Stephen Lloyd
Published 2012-01-01

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle.

by Vladimir Vartanian, Jana Tumova, Pawel Dobrzyn, Agnieszka Dobrzyn, Yusaku Nakabeppu, R Stephen Lloyd, Harini Sampath
Published 2017-01-01

MUTYH Deficiency Is Associated with Attenuated Pulmonary Fibrosis in a Bleomycin-Induced Model

by Qingmin Sun, Jingwen Chen, Lizhi Xu, Jiaqi Kang, Xin Wu, Yan Ren, Yusaku Nakabeppu, Yaping Wang
Published 2020-01-01

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model.

by Holly Simon, Vladimir Vartanian, Melissa H Wong, Yusaku Nakabeppu, Priyanka Sharma, R Stephen Lloyd, Harini Sampath
Published 2020-01-01

Neural stem cell–specific ITPA deficiency causes neural depolarization and epilepsy

by Yuichiro Koga, Daisuke Tsuchimoto, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Hiroshi Nakanishi, Shinya Toyokuni, Yusaku Nakabeppu
Published 2020-11-01

Galectin-1 and galectin-3 as key molecules for peripheral nerve degeneration and regeneration

by Hideji Yako, Hidenori Horie, Kazunori Sango, Kunihiko Sakumi, Masami Tsukamoto, Naoko Niimi, Toshihiko Kadoya, Yusaku Nakabeppu, Shizuka Takaku
Published 2016-07-01

MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis

by Sugako Oka, Julio Leon, Kunihiko Sakumi, Nona Abolhassani, Zijing Sheng, Daisuke Tsuchimoto, Frank M. LaFerla, Yusaku Nakabeppu
Published 2021-03-01

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

by Naoya Kubokura, Fumi Takahashi-Yanaga, Masaki Arioka, Tatsuya Yoshihara, Kazunobu Igawa, Katsuhiko Tomooka, Sachio Morimoto, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yusaku Nakabeppu, Takayuki Matsumoto, Takanari Kitazono, Toshiyuki Sasaguri
Published 2015-04-01

MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model

by Hiroki Sakamoto, Koji Miyanishi, Shingo Tanaka, Ryo Ito, Kota Hamaguchi, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yusaku Nakabeppu, Masayoshi Kobune, Junji Kato
Published 2021-02-01

Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

by Kyota Fujita, Toshihiro Seike, Noriko Yutsudo, Mizuki Ohno, Hidetaka Yamada, Hiroo Yamaguchi, Kunihiko Sakumi, Yukiko Yamakawa, Mizuho A Kido, Atsushi Takaki, Toshihiko Katafuchi, Yoshinori Tanaka, Yusaku Nakabeppu, Mami Noda
Published 2009-09-01

A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.

by Gabriele De Luca, Maria Teresa Russo, Paolo Degan, Cecilia Tiveron, Andrea Zijno, Ettore Meccia, Ilenia Ventura, Elisabetta Mattei, Yusaku Nakabeppu, Marco Crescenzi, Rita Pepponi, Antonella Pèzzola, Patrizia Popoli, Margherita Bignami
Published 2008-11-01

Author Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation...

by Erika Castillo, Julio Leon, Guianfranco Mazzei, Nona Abolhassani, Naoki Haruyama, Takashi Saito, Takaomi Saido, Masaaki Hokama, Toru Iwaki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Kunihiko Sakumi, Frank M. LaFerla, Yusaku Nakabeppu
Published 2021-09-01

Serum Anti-oligodendrocyte Autoantibodies in Patients With Multiple Sclerosis Detected by a Tissue-Based Immunofluorescence Assay

by Yukino Miyachi, Takayuki Fujii, Ryo Yamasaki, Daisuke Tsuchimoto, Kyoko Iinuma, Ayako Sakoda, Ayako Sakoda, Ayako Sakoda, Shoko Fukumoto, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Yusaku Nakabeppu, Jun-ichi Kira, Jun-ichi Kira, Jun-ichi Kira
Published 2021-08-01

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

by Monica D. Bjørge, Gunn A. Hildrestrand, Katja Scheffler, Rajikala Suganthan, Veslemøy Rolseth, Anna Kuśnierczyk, Alexander D. Rowe, Cathrine B. Vågbø, Susanne Vetlesen, Lars Eide, Geir Slupphaug, Yusaku Nakabeppu, Timothy W. Bredy, Arne Klungland, Magnar Bjørås
Published 2015-12-01