Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation

by Angel Lin, Angel Lin, Weam Othman Elbezanti, Weam Othman Elbezanti, Alexis Schirling, Alexis Schirling, Adel Ahmed, Rachel Van Duyne, Simon Cocklin, Zachary Klase, Zachary Klase
Published 2021-07-01

Morphine exposure exacerbates HIV-1 Tat driven changes to neuroinflammatory factors in cultured astrocytes.

by Kenneth Chen, Thienlong Phan, Angel Lin, Luca Sardo, Anthony R Mele, Michael R Nonnemacher, Zachary Klase
Published 2020-01-01

Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3ß activity.

by Norman Fultang, Abhinav Illendula, Brian Chen, Chun Wu, Subash Jonnalagadda, Nathan Baird, Zachary Klase, Bela Peethambaran
Published 2019-01-01

Transcriptional Gene Silencing (TGS) via the RNAi Machinery in HIV-1 Infections

by Fatah Kashanchi, Kylene Kehn-Hall, Aarthi Narayanan, Zachary Klase, Elizabeth Jaworski, Ravi Das, Irene Guendel, Gavin C. Sampey
Published 2012-08-01

Benzodiazepines Drive Alteration of Chromatin at the Integrated HIV-1 LTR

by Weam Elbezanti, Angel Lin, Alexis Schirling, Alexandria Jackson, Matthew Marshall, Rachel Van Duyne, Frank Maldarelli, Luca Sardo, Zachary Klase
Published 2020-02-01

Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA.

by Zachary Klase, Venkat S R K Yedavalli, Laurent Houzet, Molly Perkins, Frank Maldarelli, Jason Brenchley, Klaus Strebel, Paul Liu, Kuan-Teh Jeang
Published 2014-03-01

Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery.

by Rachel Van Duyne, Irene Guendel, Zachary Klase, Aarthi Narayanan, William Coley, Elizabeth Jaworski, Jessica Roman, Anastas Popratiloff, Renaud Mahieux, Kylene Kehn-Hall, Fatah Kashanchi
Published 2012-01-01