Development of a Method and Validation for the Quantitation of FruArg in Mice Plasma and Brain Tissue Using UPLC–MS/MS

by Mitch C. Johnson, Hailong Song, Jiankun Cui, Valeri V. Mossine, Zezong Gu, C. Michael Greenlief
Published 2016-10-01

The S-nitrosylation status of PCNA localized in cytosol impacts the apoptotic pathway in a Parkinson's disease paradigm.

by Liang Yin, Yingying Xie, Songyue Yin, Xiaolei Lv, Jia Zhang, Zezong Gu, Haidan Sun, Siqi Liu
Published 2015-01-01

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1.

by Grace Y Sun, Zihong Chen, Kimberly J Jasmer, Dennis Y Chuang, Zezong Gu, Mark Hannink, Agnes Simonyi
Published 2015-01-01

Nanometer ultrastructural brain damage following low intensity primary blast wave exposure

by Hailong Song, Landry M Konan, Jiankun Cui, Catherine E Johnson, Graham K Hubler, Ralph G DePalma, Zezong Gu
Published 2018-01-01

Yin-Yang Mechanisms Regulating Lipid Peroxidation of Docosahexaenoic Acid and Arachidonic Acid in the Central Nervous System

by Bo Yang, Kevin L. Fritsche, David Q. Beversdorf, Zezong Gu, James C. Lee, William R. Folk, C. Michael Greenlief, Grace Y. Sun
Published 2019-06-01

Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells

by Bo Yang, Runting Li, C. Michael Greenlief, Kevin L. Fritsche, Zezong Gu, Jiankun Cui, James C. Lee, David Q. Beversdorf, Grace Y. Sun
Published 2018-07-01

Histological quantitation of brain injury using whole slide imaging: a pilot validation study in mice.

by Zhenzhou Chen, Dmitriy Shin, Shanyan Chen, Kovalenko Mikhail, Orr Hadass, Brittany N Tomlison, Dmitry Korkin, Chi-Ren Shyu, Jiankun Cui, Douglas C Anthony, Zezong Gu
Published 2014-01-01

Two-dimensional zymography differentiates gelatinase isoforms in stimulated microglial cells and in brain tissues of acute brain injuries.

by Shanyan Chen, Fanjun Meng, Zhenzhou Chen, Brittany N Tomlinson, Jennifer M Wesley, Grace Y Sun, Adam T Whaley-Connell, James R Sowers, Jiankun Cui, Zezong Gu
Published 2015-01-01

Prolonged Exposure of Cortical Neurons to Oligomeric Amyloid-β Impairs NMDA Receptor Function Via NADPH Oxidase-Mediated ROS Production: Protective Effect of Green Tea (-)-Epigallo...

by Yan He, Jiankun Cui, James C-M Lee, Shinghua Ding, Malgorzata Chalimoniuk, Agnes Simonyi, Albert Y Sun, Zezong Gu, Gary A Weisman, W Gibson Wood, Grace Y Sun
Published 2011-01-01

Maternal Dietary Docosahexaenoic Acid Alters Lipid Peroxidation Products and (n-3)/(n-6) Fatty Acid Balance in Offspring Mice

by Bo Yang, Runting Li, Taeseon Woo, Jimmy D. Browning, Hailong Song, Zezong Gu, Jiankun Cui, James C. Lee, Kevin L. Fritsche, David Q. Beversdorf, Grace Y. Sun, C. Michael Greenlief
Published 2019-03-01

Dietary Sutherlandia and Elderberry Mitigate Cerebral Ischemia-Induced Neuronal Damage and Attenuate p47phox and Phospho-ERK1/2 Expression in Microglial Cells

by Dennis Y. Chuang, Jiankun Cui, Agnes Simonyi, Victoria A. Engel, Shanyan Chen, Kevin L. Fritsche, Andrew L. Thomas, Wendy L. Applequist, William R. Folk, Dennis B. Lubahn, Albert Y. Sun, Grace Y. Sun, Zezong Gu
Published 2014-10-01

Sutherlandia frutescens ethanol extracts inhibit oxidative stress and inflammatory responses in neurons and microglial cells.

by Jinghua Jiang, Dennis Y Chuang, Yijia Zong, Jayleenkumar Patel, Korey Brownstein, Wei Lei, Chi-Hua Lu, Agnes Simonyi, Zezong Gu, Jiankun Cui, George E Rottinghaus, Kevin L Fritsche, Dennis B Lubahn, William R Folk, Grace Y Sun
Published 2014-01-01

Proteomic analysis of the effects of aged garlic extract and its FruArg component on lipopolysaccharide-induced neuroinflammatory response in microglial cells.

by Hui Zhou, Zhe Qu, Valeri V Mossine, Dineo L Nknolise, Jilong Li, Zhenzhou Chen, Jianlin Cheng, C Michael Greenlief, Thomas P Mawhinney, Paula N Brown, Kevin L Fritsche, Mark Hannink, Dennis B Lubahn, Grace Y Sun, Zezong Gu
Published 2014-01-01

Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury.

by Orr Hadass, Brittany N Tomlinson, Major Gooyit, Shanyan Chen, Justin J Purdy, Jennifer M Walker, Chunyang Zhang, Andrew B Giritharan, Whitley Purnell, Christopher R Robinson, Dmitriy Shin, Valerie A Schroeder, Mark A Suckow, Agnes Simonyi, Grace Y Sun, Shahriar Mobashery, Jiankun Cui, Mayland Chang, Zezong Gu
Published 2013-01-01

S-Nitrosylation-Mediated Redox Transcriptional Switch Modulates Neurogenesis and Neuronal Cell Death

by Shu-ichi Okamoto, Tomohiro Nakamura, Piotr Cieplak, Shing Fai Chan, Evgenia Kalashnikova, Lujian Liao, Sofiyan Saleem, Xuemei Han, Arjay Clemente, Anthony Nutter, Sam Sances, Christopher Brechtel, Daniel Haus, Florian Haun, Sara Sanz-Blasco, Xiayu Huang, Hao Li, Jeffrey D. Zaremba, Jiankun Cui, Zezong Gu, Rana Nikzad, Anne Harrop, Scott R. McKercher, Adam Godzik, John R. Yates III, Stuart A. Lipton
Published 2014-07-01