Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure

Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure

Glaucoma is a leading cause of blindness, affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. It is well established that inefficient aqueous humor (AqH) outflow resulting from structural or functional alterations in ocular drainage tissu...

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Bibliographic Details
Main Authors: Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G. Tolman, Syed Hameed, Yusef Seymens, Eric Dang, Anil K. Mandal, Sirisha Senthil, Rohit C. Khanna, Meha Kabra, Inderjeet Kaur, Simon W. M. John, Subhabrata Chakrabarti, K. Saidas Nair
Format: Article
Language:English
Published: The Company of Biologists 2020-05-01
Series:Disease Models & Mechanisms
Subjects:
angle-closure glaucoma
intraocular pressure
ocular drainage defects
prss56
Online Access:http://dmm.biologists.org/content/13/5/dmm042853

Internet

http://dmm.biologists.org/content/13/5/dmm042853

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