Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic–Pituitary–Adrenal Axis Dysfunction in Stressed Withdrawn Mice

Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic–Pituitary–Adrenal Axis Dysfunction in Stressed Withdrawn Mice

This study compares the impact of repeated injections of baclofen (an agonist of GABAB receptors) or diazepam (a benzodiazepine having an agonist action on GABAA receptors) given during the alcohol-withdrawal period on the stress-induced restoration of alcohol-seeking behavior and hypothalamic–pitui...

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Bibliographic Details
Main Authors: Yolaine Rabat, Nadia Henkous, Marc Corio, Xavier Nogues, Daniel Beracochea
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Psychiatry
Subjects:
gamma-aminobutyrique acid (GABA)
ethanol
anxiety
glucocorticoids
corticosterone
benzodiazepines
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00238/full

Internet

https://www.frontiersin.org/article/10.3389/fpsyt.2019.00238/full

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