Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii

Abstract Background Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enzymes which generate acetyl-CoA in the nucleo-cytos...

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Bibliographic Details
Main Authors: Joachim Kloehn, Rebecca D. Oppenheim, Ghizal Siddiqui, Pieter-Jan De Bock, Sunil Kumar Dogga, Yohann Coute, Mohamed-Ali Hakimi, Darren J. Creek, Dominique Soldati-Favre
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Biology
Subjects:
Toxoplasma gondii
Acetyl-CoA
Branched-chain α-keto acid dehydrogenase-complex (BCKDH)
ATP citrate lyase (ACL)
Acetyl-CoA synthetase (ACS)
Acetylome
Online Access:http://link.springer.com/article/10.1186/s12915-020-00791-7

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http://link.springer.com/article/10.1186/s12915-020-00791-7

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