Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope prot...

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Bibliographic Details
Main Authors: Florian Köhler, Felix Bormann, Günter Raddatz, Julian Gutekunst, Samuel Corless, Tanja Musch, Anke S. Lonsdorf, Sylvia Erhardt, Frank Lyko, Manuel Rodríguez-Paredes
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Genome Medicine
Subjects:
Hutchinson-Gilford progeria syndrome
Epigenetics
Aging
Lamina-associated domains (LADs)
DNA methylation
Chromatin accessibility
Online Access:http://link.springer.com/article/10.1186/s13073-020-00749-y

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http://link.springer.com/article/10.1186/s13073-020-00749-y

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