COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro

<p>Abstract</p> <p>Background</p> <p>An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex<sup>®</sup>) is mediated primarily via the inhibition of COX-2. We have investiga...

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Bibliographic Details
Main Authors: Petasis Nicos A, Gaffney Kevin J, Kardosh Adel, Chuang Huan-Ching, Schönthal Axel H
Format: Article
Language:English
Published: BMC 2008-05-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/7/1/38